A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

An adaptor for coupling with a medical container, including: a tubular body receiving a pierceable elastomeric piece, defining an inner cavity of the adaptor, the pierceable elastomeric piece being movable within the tubular body between a first position, in which a distal part of the pierceable elastomeric piece forms a seal of the cavity, and a second position, proximally spaced from the first position, in which the distal part opens the seal of the cavity, an air inlet, a filtering system for filling the inner cavity with decontaminated air, and a gripping member for securing the adaptor to the medical container. Also, an assembly comprising such an adaptor and a medical container.

According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.

Device (100) for reconstituting an active ingredient in sterile powder, comprising a vial (4) containing the active ingredient; a flexible bag (1) containing a sterile liquid; a connecting component (5) secured to the vial (4) and to the flexible bag (1); an elastomeric sealing ring (10) arranged between the connecting component (5) and the vial (4), an axially perforated spike (7), constrained to the connecting component (5), wherein a sterile chamber (70) is provided, delimited by the vial (4), by the connecting component (5) and by the sealing ring (10, 110), whereby the active ingredient is reconstituted in sterile conditions.

A syringe adapter is provided. The adapter includes a housing having a first end and a second end positioned opposite the first end. The first end of the housing has a connector configured to be secured to a syringe barrel. The adapter also includes a cannula positioned within the housing and a seal arrangement including a membrane or septum positioned within the housing and movable within the housing, the seal arrangement comprising a membrane. The assembly can also include a protective cap having a first open end and a second closed end. The protective cap can be connected to the housing via a snap fit and can be configured to receive the second end of the housing.

A device holder (20) that holds a transfer device (800) is provided on a stage (10). The device (800) includes a first connector (810) to which a first container (910) is connectable, a second connector (820) to which a second container (950) is connectable, and a connection port (850) to which a syringe (980) is connectable. The stage (10) can be turned to a first turning position where the first connector (810) is located higher than the second connector (820) and a second turning position where the second connector (820) is located higher than the first connector (810). A second container holder (50) that holds the second container (950) coaxially with the second connector (820) turns together with the stage (10) and can be linearly moved along a direction of an axis of the second connector (820).

The present invention relates, in some embodiments thereof, to systems, devices, connection ports, and methods allowing for an engagement of two or more pharmaceutical vessels, containers, or pharmaceutical administration devices in a decontaminated and/or sterile manner. In some embodiments of the invention, the systems, devices, connection ports, and methods of the invention include a dual decontamination action device having a wiping member and a removable sealing member, a system comprising a device having a wiping member and a removable sealing member and a connection port having a removable sealing member. A first removable sealing member attached to a housing of a device is provided, the housing further comprising a wiping member configured to move across the housing; and a connection port having a removable sealing member, both removable sealing members configured to displace from the engagement between the device and the connection port while a hermetically sealed connection is maintained between the device and the connection port. In some embodiments of the invention, the systems, devices, connection ports and methods include a wiping member that is configured to wipe off the surface(s) of the engaged device and connection port, thus providing a decontaminated/sterile fluid communication between the device and the connection port.

A drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.

A system including an adapter for sequential engagement with a cartridge containing a first substance and a vial containing a second substance is disclosed. The adapter is configured to first engage with the vial and subsequently engage with the cartridge such that the cartridge is in fluid communication with the vial via the adapter. The system includes a latch member engageable with a portion of the cartridge. A plunger rod includes a protrusion and is adapted to communicate with the latch member, the plunger rod being transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge and locked to the plunger rod.

A connection system for connecting a first medical device component to a second medical device component is disclosed. The connection system of the present disclosure provides for quick and intuitive coupling and decoupling of two opposing medical device components through the use of a connection path and a disconnection path, the connection path being distinct from the disconnection path. Furthermore, the connection system of the present disclosure provides audible and tactile connection feedback through the use of elastically deformable connection elements.