A cartridge for dispensing a pre-measured buffering agent together with a medical fluid such as dental anesthetic. The cartridge includes a sharp piercing element at one end, a frangible barrier proximate the piercing element, and a traveling closure. The buffering solution is in a chamber between the barrier and the closure. When loaded into a syringe and subjected to operating pressures, the barrier is pierced, enabling the buffering solution to mix with the medical fluid. Continued pressure propels a desired, controlled mixture into a tissue of a patient. A dye may be included for visual confirmation of mixing. The invention may be regarded as the cartridge, a syringe having the cartridge, or a kit, with or without a syringe, or cartridges having closures of different types.

Various embodiments of the present invention are directed to transferring fluidic media from a vial to a reservoir. In various embodiments, fluidic media may be transferred from the vial to the reservoir by moving a housing portion to move a plunger head located in the reservoir to draw fluidic media from the vial to the reservoir. In other embodiments, fluidic media may be transferred from the vial to the reservoir while the reservoir is held by a holding unit and vibrated by a vibrator to remove air from the fluidic media. In some embodiments, fluidic media may be transferred from the vial to the reservoir by moving a handle operatively connected to a bias member for assisting with the transfer of fluidic media. In other embodiments, the transfer of fluidic media may be assisted by a bias member and a needle connecting atmosphere and the vial.

Dual vial adapter assemblages having a triple component construction as follows: a first vented female vial adapter for telescopic mounting on a drug vial, a second vented female vial adapter for telescopic mounting on a liquid vial and a tubular liquid transfer coupler for coupling the first vented female vial adapter and the second vented female vial adapter for establishing a dual sealed lumen arrangement therebetween. The dual sealed lumen arrangement includes a central sealed liquid lumen for gravitational flow of liquid contents from a liquid vial to a drug vial and a sealed air lumen radial outward from the central sealed liquid lumen for venting air displaced from the drug vial to the liquid vial for assisting the gravitational flow of liquid contents by creating a closed system between the liquid vial and the drug vial.

Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include applying AP magnetic fields having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to a target body area that includes the cancer or other rapidly-dividing cells.

A double-layer medical fluid bag includes an inner wall, an outer wall, clean air filled between the inner and outer walls, and a piercing device installed between the inner and outer walls. When it is necessary to use a liquid medicine contained in the medical fluid bag, the piercing device is moved forward to pierce a plate to be pierced, so that the clean air can enter into the inner wall slowly to push the liquid medicine to flow downwardly to the outside. During the operation and use processes, the liquid medicine is completely isolated from outside air, so as to avoid the danger of having unknown outside air to enter into the medical fluid bag and endure the safety of using the medical fluid bag.

A liquid medicine filling device includes a container mounting unit, a liquid delivery flow conduit, a ventilation flow conduit, a syringe, a connection flow conduit, a first flow path switching unit, and a second flow path switching unit. The first flow path switching unit may switch between a flow path for filling through which the syringe communicates with a liquid medicine container via the ventilation flow conduit and a flow path for air removal through which the syringe communicates with the connection flow conduit via the ventilation flow conduit. The second flow path switching unit may switch between a flow path for filling through which the liquid medicine container communicates with the liquid medicine storage unit via the liquid delivery flow conduit and a flow path for air removal through which the liquid medicine storage unit communicates with the connection flow conduit via the liquid delivery flow conduit.

An apparatus to preserve liquid from a medicine vial may include a vial coupling member forming a vial coupling member cavity and a container forming a cavity. The apparatus may further include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity and the cavity and a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity and the cavity. The vial coupling member cavity, the cavity, the first lumen, and the second lumen may form a sterile environment that is sealed from contaminants in an ambient environment. The apparatus may include a disengaging member configured to permit the container to disengage from the first fluid pathway and the second fluid pathway while permanently sealing at least one of the first lumen or the second lumen.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

A drug mixing device is disclosed. The drug mixing device comprises a first container for holding a first component of a drug to be mixed, a second container for holding a second component of the drug to be mixed, fluidly coupled to the first container; and a fluid driver fluidly coupled to the first container and configured to drive a driving fluid into the first container. The mixing device is arranged such that, in use, when the fluid driver drives the driving fluid into the first container, at least some of the first component of the drug to be mixed flows to the second container.

The present invention relates to a device for vacuum and vent tube stoppering a medical container. The device includes a main body defining an internal volume that has a first variable pressure chamber configured to be connected to a vacuum pump, the main body being configured to receive the proximal end of a medical container so that said medical container is in communication with the first variable pressure chamber. A vent device including a vent tube is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position. A piston rod is moveable inside the internal volume of the vent tube along the longitudinal axis between a proximal rest position and a distal operative position. A container holder system is provided in the main body, in communication with the first variable pressure chamber.