A closed fluid transfer system for fluidly interconnecting a syringe to any one of a patient I.V. set, a vial and an I.V. bag, is provided and includes a first adapter defining a lumen and supporting a seal across a first end of its lumen, the first adapter supporting a rear end of a needle within the lumen, wherein the seal is movable relative to the needle such that a tip of the needle penetrates through the seal; and a second adapter defining a lumen and supporting a seal across a first end of its lumen; wherein when the second adapter is coupled to the first adapter, the second adapter seal abuts the first adapter seal and moves the first adapter seal relative to the tip of the needle such that the tip of the needle penetrates through the abutting first adapter seal and second adapter seal.

Compositions and methods for separating a sample of whole blood or bone marrow aspirate into a fraction rich in at least one of platelets and pluripotent cells are provided. A sample of whole blood can be centrifuged in a collection tube comprising a separator substance formulated to settle between the PRP fraction and the at least one other fraction. Preferably, centrifugation is completed without substantial activation of platelets. Optionally, the separator substance could be hardened to form a solid barrier that allows removal of all or substantially all of the platelets in the PRP fraction without remixing of the PRP fraction with the at least one other fraction. Transfer devices and methods are also provided in which a sterile sample can be transferred from a separation/preparation container (e.g., vacutainer) to a consumer or other container (e.g., dropper) while maintaining sterility of the sample.

A medical container assembly is disclosed having an adapter assembly that fluidly connects with a medical container having a volume of medical fluid to accommodate multiple injections. The adapter assembly includes a spike assembly (300) that fluidly connects with the medical container, along with a spike interface cover (200) that detachably connects with the spike assembly (300). Features are incorporated by the spike assembly (300) to reduce the potential that the spike assembly (300) will be used with multiple medical containers. The spike interface cover (200) is detachably connected with the spike assembly (300) and includes features that allows the spike interface cover (200) to be used with a spike assembly (300) installed on one container, and to thereafter allow this same spike interface cover (200) to be used with another spike assembly (300) installed on another container.

A filter system for a closed fluid transfer system with pressure equalization. The filter system includes a filter having a main flow direction for a fluid passing through the filter extending from a fluid inlet surface to a fluid outlet surface, and a filter housing. The filter has a greater or at least equal extension in the main flow direction compared to at least one direction transverse to the main flow direction.

The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

A vial adaptor (1010) may comprise a body portion (1020). The body portion includes a vial connection port (1022), a syringe connection port (1024), an access passageway (1026) between the vial connection port and the syringe connection port, and a regulation passageway (1028). The vial adaptor may further comprise an expandable and/or contractible chamber (1040) impermeable to gas and/or liquid, the regulation passageway being between the vial connection port and the chamber, and an expandable housing (1050) casing the chamber. Such a vial adaptor constitutes an improved vial adaptor.

A container for medical liquids comprises an inner container having a distal end and a proximal end, a first porous separating element being arranged at the proximal end, the first porous separating element delimiting a holding volume for holding a medical liquid, and comprising an outer container, in which the inner container is arranged with the proximal end and with at least portions of the holding volume. The outer container extends around the inner container gas-tight such that a gas under positive pressure can be arranged in a peripheral volume arranged between an outer surface of the inner container and an inner surface of the outer container. An outlet channel section is connected to the distal end of the inner container. At least portions of the outlet channel section are arranged outside of the outer container. A valve device can be arranged in the outlet channel section, which valve device is designed, in an open position, to open a fluid connection between a distal outlet opening of the outlet channel section and the holding volume and, in a closed position, to block the fluid connection between the distal outlet opening and the holding volume.

A medical fluid transfer apparatus for transferring hazardous liquid medication in a fluid-tight manner. The apparatus includes a first connector portion having a first passage for fluid-tight connection to a medical syringe; a second connector portion having a second passage for fluid-tight connection to a medical liquid reservoir; a fluid channel extending between the first passage and the second passage, which permits a fluid-conducting transfer of the medication liquid between the syringe and the liquid reservoir; and an equalization container having an equalization volume, which is connected to the liquid reservoir in a fluid-conducting manner, and which is designed to receive a gas volume displaced during transfer of the medication liquid out of the liquid reservoir. The first passage and the second passage are connected to each other in a fluid-conducting manner via the equalization volume, which forms a fluid channel portion of the fluid channel.

The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Systems and methods for destroying or inhibiting cancer cells and other rapidly-dividing cells include coupling an alternating polarity (AP) magnetic field generator to a target body area and applying an AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug.