In some embodiments, a reconstitution or medicinal fluid delivery device includes a transfer engine including two fluidly connected spikes, each configured to pierce a container. A check valve may be disposed between the two spikes to allow unidirectional flow from one container to the other. Physical access to a fluid outlet may be obstructed by a housing until the reconstitution or medicinal fluid delivery device is actuated, whereupon physical access to the fluid outlet is permitted. The reconstitution or medicinal fluid delivery device may be placed on a flat surface and actuated with force applied in a single direction toward the flat surface.

A sampling device is disclosed. The sampling device includes a cannula and a guide component coupled to the cannula. The cannula includes a top portion and a bottom portion. Moreover, the cannula includes an inner diameter. The bottom portion includes a distal end that is configured to pierce or puncture a cap of a bottle. The guide component includes a lateral portion and a vertical portion. The lateral portion extends radially out from the cannula and the vertical portion is coupled to an outer edge of the lateral portion. The vertical portion extends down from the lateral portion substantially parallel to the cannula and beyond the distal end of the bottom portion.

A device for reconstituting a bioactive agent and forming a flowable paste is described. The device comprises a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.

Apparatus and method are described employing pressurized gas to transfer, mix and/or reconstitute medicament contained in a vial and flowing it into an injection device. Pressurized gas may be provided by prefilled cartridge.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

A bottle connector for use in a medical fluid transfer arrangement, the bottle connector having an axial direction and a radial direction and comprising a first part and a second part, the first part comprising a hollow piercing member comprising an inner gas channel and extending in the axial direction beyond the end of the first part. The second part comprises a bottle coupling member, for coupling the bottle connector to a medical bottle. The first and second parts are pre-connected and are concentrically arranged with respect to each other and the bottle connector has a transport configuration with a first, maximum length in which the piercing member is completely located within the bottle connector, and a fluid transfer configuration with a second, minimum length.

Dual vial adapter assemblages including two identical twin vial adapters each having an upright vial adapter connector of a first connector type and a dual ended liquid transfer coupler interdisposed between the two identical twin vial adapters and having a pair of opposite coupler ends in the form of twin connectors of a second connector type for sealed engagement with the vial adapter connectors of the first connector type.

Dual vial adapter assemblage for use with a drug vial and a liquid vial and including a vented drug vial adapter and a vented liquid vial adapter such that simultaneous venting of the liquid vial and the drug vial assists gravitational flow of liquid contents from the liquid vial into the drug vial for forming liquid drug therein.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial. In order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

A device for aseptic delivery of biological material from a vial includes a tubular barrel, a filter assembly, and a dispersion assembly. The dispersion assembly is at least partially disposed within the tubular barrel. The dispersion assembly includes a dispersion element, a piston, and a one-way valve. The dispersion element is in fluid communication with the vial to disperse the biological material from the vial. The piston is disposed at the distal end of the dispersion assembly and is in sealing contact with the tubular barrel. The one-way valve forms a fluid passageway in fluid communication with the dispersion element and the tubular barrel. The one-way valve is configured to allow a flow of the dispersed biological material from the dispersion element, through the fluid passageway, and into the tubular barrel, and to prevent a flow of the dispersed biological material from the tubular barrel into the dispersion assembly.