An exemplary vial adapter may include a moveable member, an elongated member with a first passage, a second passage coupled to an expandable first reservoir, and a third passage coupled to an expandable second reservoir. In a first orientation of an exemplary vial adapter, a fluid may be directed through the first passage into the first reservoir or the second reservoir. In a second orientation of an exemplary vial adapter, a fluid may be drawn through the first passage and a fluid drawn through an air passage into the second passage. In a second orientation of an exemplary vial adapter, a fluid may be directed through the first passage and through the third passage into the second reservoir. In a first orientation of an exemplary vial adapter, a moveable member may be activated to direct a fluid from the second reservoir through the third passage.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Some embodiments disclosed herein related to a device for transferring precise amounts of fluid from at least one source container to at least one target container. In some embodiments, the fluid is first transferred from the source container (e.g., a vial) through a connector to an intermediate measuring container (e.g., a syringe). In some embodiments air can pass through an air inlet and enter the vial to compensate for the volume of fluid withdrawn from the vial. An air check valve or a bag or a filter can prevent the fluid from escaping through the air inlet. The precisely measured amount of fluid can then be transferred from the intermediate measuring container to the target container (e.g., an IV bag). In some embodiments the connector can include a source check valve and a target check valve to direct fluid first from the source container to the intermediate measuring container and then from the intermediate measuring container to the target container. Some embodiments of the device can include a motor and a controller for automatically actuating a plunger of the syringe to transfer the desired amount of fluid.

A dispensing device, comprising: a piston-cylinder assembly, the assembly comprising an outlet in fluid communication with a one-way valve and an inlet in fluidic communication with a valve assembly; the one-way valve configured to dispense a liquid from a medicament container, the valve assembly fluidically coupled to the one-way valve, the valve assembly having at least one cannula and at least one flow control member; the piston configured to draw an amount of fluid through the valve assembly and inlet into the cylinder, and to expel the amount of liquid through the one-way valve; and an actuator assembly coupled to and biasing the piston with stored energy.

A method for treating a medical condition of a patient with Alpha-2 Macroglobulin (?2M) molecules in an allogeneic or xenogeneic manner, the method includes: drawing whole blood from a donor, separating plasma containing ?2M molecules from other components of the whole blood; isolating the ?2M molecules from the other components of the plasma; and administering at least some of the isolated ?2M molecules to the patient via injection or inhalation, wherein the donor and the patient are different individuals.

A closed system transfer device includes a first adaptor and a second adaptor that attach with one another in a coupled state to form a sealed fluid passage between two reservoirs. The first adaptor can be attached to a first reservoir, and the second adaptor can be attached to a second reservoir. One or both adaptors can include a septum that engages another septum during coupling and decoupling to prevent liquid or vapor from being released to the environment. The device can also include a vent line that equalizes pressure between the two reservoirs. The vent line can include at least one filter to filter gas in device. In addition, or in the alternative, the vent line can be connected in fluid communication with an inflatable membrane that stores gas inside the device and assists in equalizing pressure.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. The regulator assembly can include a valve configured to transition between a closed configuration and an opened configuration.