Provided are a method for producing a platelet lysate, a production system, and a bag set capable of efficiently producing a platelet lysate with a simple device structure. According to the method for producing a platelet lysate, by which a platelet lysate (PL) that contains a growth factor contained in platelet is produced, buffy coat is collected from whole blood; the buffy coat (BC) is centrifuged to extract a supernatant, thereby collecting a platelet concentrate from which leukocyte has been removed; and, prior to freezing, the platelet concentrate is centrifuged to remove the supernatant, thereby preparing a highly concentrated platelet concentrate. The highly concentrated platelet concentrate is then frozen and thawed, and further centrifuged to recover the platelet lysate.

A filter system for a closed fluid transfer system with pressure equalization. The filter system includes a filter having a main flow direction for a fluid passing through the filter extending from a fluid inlet surface to a fluid outlet surface, and a filter housing. The filter has a greater or at least equal extension in the main flow direction compared to at least one direction transverse to the main flow direction.

The present disclosure is directed to adapters for mixing vials of drug products, and more specifically to multi-vial adapters for reconstituting lyophilized drug products and/or diluting concentrated drug products. It is an object to address one or more of drawbacks in connection with the drug preparation process, for example, by simplifying the procedure where multiple vials are required to be diluted or reconstituted in a serial manner. As such, the multi-vial adapters described herein simplify the complexity of preparing and handling multiple vials of drug product, which significantly reduces preparation time, addresses dosing-related challenges like weight-based preparation, reduces drug waste issues, and reduces risks associated sterility and contamination, among other benefits.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure

According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.

A filter system for a closed fluid transfer system with pressure equalization. The filter system includes a filter having a main flow direction for a fluid passing through the filter extending from a fluid inlet surface to a fluid outlet surface, and a filter housing. The filter has a greater or at least equal extension in the main flow direction compared to at least one direction transverse to the main flow direction.

A medical fluid injection device, a medical fluid transfer device and a method of administering and transferring a medical fluid are disclosed. The device and method may include a compressed gas canister in fluid communication with an expandable elastic bladder positioned within a vial of drug to provide a means to deliver drug through an injection cannula that is movable between a plurality of positions or through a transfer conduit.

The invention relates to a kit comprising a vial and a male connector (6) comprising: a male part (8) suitable for being inserted in a female connector of the vial, the male part having an outer surface (12) extending around an axis (X) and tapering towards a free end (2) of the male part (8); a sleeve (14) extending around and at a distance from the male part (8), the sleeve (14) comprising an internal thread (20) suitable for cooperating with an external thread of the female connector when the male part (6) is inserted in the female connector, the outer surface (12) comprising a first frustoconical portion (12b) forming a first angle () with respect to the axis (X), and a second frustoconical portion (12c) extending the first frustoconical portion (12a) towards the free end (2), the second frustoconical portion (12c) forming a second angle () with respect to the axis (X), the second angle being less than the first angle ().

A medical fluid injection device, a medical fluid transfer device and a method of administering and transferring a medical fluid are disclosed. The device and method may include a compressed gas canister in fluid communication with an expandable elastic bladder positioned within a vial of drug to provide a means to deliver drug through an injection cannula that is movable between a plurality of positions or through a transfer conduit.