In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

A syringe system includes a syringe and a filtration device connected to the syringe for sterilizing and introducing fluid into the syringe. The syringe includes a syringe barrel having a proximal end defining a barrel opening, a distal end defining a delivery opening, a bore extending between the proximal end and the distal end, and a stopper disposed in the bore of the syringe barrel. The filtration device has an inlet and an outlet coupled in fluid communication with the delivery opening at the distal end of the syringe barrel. The filtration device includes a stem and a filter membrane disposed in line with the stem. The filter membrane optionally has a plurality of pores each with a nominal pore size in a range of approximately 0.1 m to approximately 0.5 m such that a pharmaceutical fluid can be introduced as a sterilized pharmaceutical fluid into the bore of the syringe barrel by passing through the filtration device.

A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.

A convenience kit for sterilizing and delivering liquids into the safety of a sterile environment inside a plastic bag (which can be disposed in a field environment) wherein a so sterilized liquid is dispensed into a vessel which is capped and sealed before removal from the bag. The convenience kit can be provided in a solitary format or, as a subkit combined with other associated items in a more inclusive convenience kit. In short, convenience kits made according to the present invention provide opportunity for accomplishing an aseptic liquid sterilizing transfer, a task which is commonly associated with on-hand capability of a laminar flow hood, in field environments and other areas which are remote from facilities having laminar flow hoods.

A bone fragment and osteomedullary tissue harvesting system that includes a harvesting device, a collection vessel and tubing. The harvesting device includes a needle portion and a handle portion. The needle portion that has a needle bore that extends through at least part of the needle portion. The handle portion is operably attached to the needle portion. The handle portion includes a connection port and a vacuum control mechanism that are in communication with a handle bore that extends through the handle portion. The needle bore is in communication with the handle bore. The vacuum control mechanism includes a vacuum aperture that extends through a surface of the handle portion and is in communication with the handle bore. The collection vessel is capable of receiving aspirated bone fragments and tissue. The tubing operably connects the connection port and the collection vessel.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial. In order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

The present invention relates to a filtering injection needle assembly for a syringe, and more particularly, to an apparatus for further facilitating suction of an injection liquid. The filtering injection needle assembly includes an injection needle (100) including a needle (110) and a hub (120); and a cap (200) configured to receive the needle (110) and including a filter (210), wherein the hub (200) is formed with a through-hole (121) for communication between an inside and an outside of the hub, and opening/closing of the through-hole (121) is controlled by a one-way valve means (300). The filtering injection needle assembly blocks foreign substances introduced into the syringe, thereby enhancing safety, and wherein the filtering injection needle assembly has various types of one-way valve means provided in the hub of the injection needle to further facilitate the suction of the injection liquid.

A device (1) and method for media filtration with a preparation container (2). A chamber (5) containing a dissolvable medium (29) is situated between the container inflow and outflow, and has a filter (22). A mixing arm (6, 7), connected to the inflow, protrudes into the medium in the chamber with at least one mixing nozzle (19, 20), disposed at the free end (17, 18) of the mixing arm for generating a directed jet of solvent. The preparation container has bottom (10) and top (8) parts bracketing the chamber. The filter is a sterile, has on the filtrate side facing the outflow, a circumferential outer edge (23) resting on a circumferential rest edge (37) of the bottom part of the preparation container and is connected fixedly thereto. A sterilised filtrate space (39) is formed between the filtrate side (38) of the filter and the outflow situated in the bottom part.

A sealed sterile device for the aseptic separation and concentration of biological components, which includes: a tube sealed at first end and which has a mouth at second end; a plunger of flexible material, without an actuation rod, installed inside the tube with the possibility of longitudinal movement, and which has a hole for charging with a fluid to be separated and concentrated and discharging the separated fractions, the hole being provide with a valved female Luer lock connection, the plunger also having a purging duct provided with a self-sealing filter for the automatic purging of the air/gas contained in the tube during the filling of the tube with the fluid to be separated and concentrated; and a cap for protecting the connection-plunger assembly, couplable to the mouth of the tube.

Disclosed is a disposable needle filter apparatus with a universal truncated syringe-receiving neck to enable the filtration of fluids/solutions aspirated into a needle-bearing syringe. The apparatus includes a needle seal stopper and needle stop to create a substantially airtight chamber to facilitate fluid aspiration through an enclosed filter and into the syringe. In an alternative embodiment, the filter apparatus includes an extended syringe-receiving neck configured to receive a specifically sized syringe/needle combination. In a further embodiment, the receiving neck is constructed as a modular unit to allow for interchangeable necks to accommodate different needle and syringe sizes with different cross-sectional diameters. In a yet further embodiment, the neck is constructed with stepped tapered segments of serially larger cross-sectional diameters to accommodate differently sized syringes. In a still further embodiment, the apparatus includes an accessory needle secured to the apparatus inlet.