The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.

The present invention relates to five-layered pigments based on multi-coated platelet-shaped substrates which comprise a layer sequence comprising (A) a layer of SnO.sub.2 having a layer thickness of 0.1-50 nm, (B) a high-refractive-index coating consisting of TiO.sub.2 in the rutile modification having a layer thickness of 10-800 nm, (C) a colorless coating having a refractive index n1.8 having a layer thickness of 20-800 nm, (D) a high-refractive-index coating consisting of SnO.sub.2 having a layer thickness of 0.1-50 nm, (E) a layer of TiO.sub.2 in the rutile modification having a layer thickness of 10-800 nm,
and optionally (F) an outer protective layer,
and to the use thereof in paints, coatings, powder coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, as dopants for the laser marking of papers and plastics, in cosmetic formulations and for the preparation of pigment preparations and dry preparations.

A new material efficiently attenuating transmission of near-infrared light is provided. A provided near-infrared-shielding material includes a plurality of flaky particles, wherein each of the plurality of flaky particles includes a flaky substrate and a single-layer film formed on a principal surface of the flaky substrate, and the near-infrared-shielding material has a light reflectance of 40% or more between wavelengths of 800 nm and 1400 nm. The flaky substrate is, for example, a glass flake. The glass flake has an average thickness of, for example, 0.6 m or less. The single-layer film includes, for example, titanium oxide and has an average thickness of, for example, 80 nm to 165 nm.