Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.

The invention relates to multi-action dermatological compositions that provides lightening, protecting and anti-aging effects to the skin of a user. The composition comprises niacinamide, arbutin, tranexamic acid, ubiquinone, a DHEA-like component, curcuma oily extract and marine exopolysaccharides. The invention also relates to methods of dermatological treatment and a method of treating hyperpigmentation by applying the composition to the skin of a user.

A method for screening compounds and compositions that reduce cetyl pyridinium chloride activation of TRPA1 receptor or TRPV1 receptor.

The invention relates generally to new compounds of formula (I), wherein R.sub.1, R′.sub.1, R.sub.2, R′.sub.2, R.sub.3, R′.sub.3, R.sub.4 R′.sub.4, R.sub.5, R′.sub.5, R.sub.6, R.sub.7 are independently of one another and denote hydrogen, hydroxyl, C.sub.1 to C.sub.6-alkyl group or R.sub.6 and R.sub.7 form together a C5-C6 ring system, and wherein n=0, 1, 2, 3, or 4. Moreover, the invention relates to the use of one or more compounds of formula (I) in cosmetic or pharmaceutical compositions, which are preferably dermatological compositions and are preferably used topically. ##STR00001##

The present disclosure relates to methods for treating hair, which are particularly useful for repairing, strengthening, and protecting hair from damage. The methods include applying to the hair each of the following components, together, separately, or in any combination thereof, in one or more hair-treatment compositions: (a) at least one amino acid or amino sulfonic acid, and/or a salt thereof, which is present in at least one of the one or more hair-treatment compositions in an amount of at least 0.5 wt. %; (b) at least one non-polymeric mono, di, or tricarboxylic acid, and/or a salt thereof, which is present in at least one of the one or more hair-treatment compositions in an amount of at least 0.5 wt. %; and (c) at least one non-taurate surfactant, which is present in at least one of the one or more hair-treatment compositions.

Hair treated with the methods exhibit desirable cosmetic properties such as smoothness, gloss, improved combability, and improved strength and elasticity.

The invention relates to a cosmetic composition which comprises: (i) one or more anionic surfactants, (ii) at least 3.5% by weight of one or more fatty acids, relative to the total weight of the composition, and (iii) one or more antidandruff agents, the anionic surfactant(s)/fatty acid(s) weight ratio being from 0.5 to 3.5. The invention also relates to the use of said composition for washing and conditioning the hair.

A method for reducing the appearance of post-acne marks, lightening dark spots and discoloration, fading post-acne marks faster and/or preventing appearance of new post-acne marks by applying a skin care composition. The skin care composition contains a vitamin B.sub.3 compound, hydroxycinnamic acid, and water at a pH of less than 5.0.

Disclosed is a method of improving the appearance of skin with a low-pH skin care composition that contains hydroxycinnamic acid (HCA) and a vitamin B3 compound in a synergistic combination.

A low-pH, aqueous skin care composition, comprising: a) 0.1 to 10% of a hydroxycinnamic acid (HCA); and b) 0.1% to 5% of a hydrotrope selected from the group consisting of: phenolic acid, derivatives of phenolic acid, phenolic alcohol, derivatives of phenolic alcohol, and mixtures thereof; wherein the hydrotrope has a pKA less than the formula pH; and wherein the hydrotrope has the partition coefficient (logP) of less than 3.0; c) water, and wherein the pH of the composition is less than 5.0.

Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.