Compositions are provided that contain biologically active components of amniotic fluid including growth factors and other proteins, carbohydrates, lipids, and metabolites. The compositions containing biologically active components of amniotic fluid can be useful for a range of therapeutic treatments including joint and soft tissue repair, regulation of skin condition, and for use in organ preservation, such as for use in organ transplant procedures. Advantages of the compositions include that they can be reproducibly produced, without the inherent variability of amniotic fluid from individual donors, and that they are free of fetal waste.

The present invention may provide a pharmaceutical composition for preventing or treating skin diseases, a cosmetic composition for preventing or improving skin diseases, and a stem cell therapeutic agent, which comprise an induced pluripotent stem cell-derived mesenchymal stem cell (iMSC), a culture thereof, or an exosome isolated from an iMSC or iMSC culture as active ingredients. When the composition of the present invention, etc. is used, it is possible to provide a composition for improving, preventing or treating skin diseases and a stem cell therapeutic agent which have an improved immunomodulating function over conventional mesenchymal stem cells.

A topical composition for treating age spots and wrinkles includes at least one first skin-whitening agent, at least one wrinkle-reducing agent, and a pharmaceutically or cosmetically acceptable solvent. In a preferred embodiment, the composition includes two whitening agents and two wrinkle-reducing agents. The skin-whitening agents include a tyrosinase-inhibiting glycosylated hydroquinone and a blend of alpine plant-based extracts. The wrinkle-reducing agents include avian egg extract and stabilized vitamin C.

Disclosed is a method for preparing a low-molecular weight horse placenta enzyme hydrolysate. According to the present invention, through development of pretreatment and optimal enzymatic treatment, the horse placenta extract can be modified to a low-molecular weight. The low-molecular weight horse placenta hydrolysate obtained according to the present invention can exhibit excellent skin permeability due to low molecular weight.

The invention discloses an oil-free additive for hair and scalp conditioning, which includes the following ingredients in percentage: 50% pure water, 5% sodium stearoyl lactylate, 10% vitamin E, 10% histidine, 1.5% anhydroxylitol, 3.5% hydrolyzed wheat protein, 7% allantoin, 5% hydrolyzed albumen and 8% carnosine. The invention has following characteristics: 1. It is the first oil-free formula in the field of hair care, so related products produced with the additive will not block hair follicles on scalps, thus leaving no residue and bringing no burden to hair care; 2. It can effectively reduce chemical damages occurred during hair perming and dyeing, and neutralize chemical residue; 3. Being non-irritating and corrosion preventing, it neutralizes residual calcium compounds in the hair, calcium carbonate and magnesium carbonate, thereby inhibiting hair splitting effectively; 4. It can greatly reduce adverse effects of organic compounds on human skin and hair, and play a role of preventing alopecia and oxidation, moisturizing and protecting skin from sun exposure. In addition, it is completely biodegradable and environment-friendly.

The present invention relates to a cell-free, stem cell conditioned medium and a process for preparation thereof. Further, the present invention relates to a therapeutic composition comprising the said stem cell conditioned medium for therapeutic and cosmetic purposes. Additionally, the present invention relates to a method for treating dermatological conditions and aiding in hair regeneration by administering the composition of the present invention.

Provided herein is a non-invasive transportation method, relating to the field of transdermal transportation, which is capable of improving absorption of active ingredients by skin. The non-invasive transportation method comprises: applying needlelike crystals onto the skin, wherein the needlelike crystals form a micro-channel array in epidermis. The method is applicable to transdermal transportation of active ingredients, and more commonly used in cosmetic methods.

Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.

A topical composition for treating age spots and wrinkles includes at least one first skin-whitening agent, at least one wrinkle-reducing agent, and a pharmaceutically or cosmetically acceptable solvent. In a preferred embodiment, the composition includes two whitening agents and two wrinkle-reducing agents. The skin-whitening agents include a tyrosinase-inhibiting glycosylated hydroquinone and a blend of alpine plant-based extracts. The wrinkle-reducing agents include avian egg extract and stabilized vitamin C.

A cosmetic composition for the repair and remodeling of the human skin is provided. The cosmetic composition includes a therapeutically effective amount of human birth tissue material and a suitable carrier composition. Methods of treating human skin with the cosmetic composition, methods of reducing the appearance of a skin condition arising from aging and a corresponding kit are also provided.