Provided herein are growth factor concentrates, the method of preparing the growth factor concentrates, cosmetic compositions and methods for cosmetic treatment. The growth factor concentrates include decapsulated growth factors derived from platelet rich plasma.

A process to increase hair growth and hair caliber which uses stem cells derived from acellular extracellular matrix, e.g., from urinary bladder and is combined with a nutrient rich medium of autologously harvested platelet rich plasma has been developed. Preferably, a microneedling device is used to induce micro wounds aids in the healing process of the hair bearing skin by converting the stem cells in the matrix to progenitor cells.

This invention relates to methods of improving the appearance of skin or hair. In particular, it relates to cosmetic products such as creams and serums comprising a subject's own platelet rich plasma (PRP). The invention also relates to kits that allow the user to apply the cosmetic products daily for several days.

A skincare stimulant having an effective dose of platelets and pharmaceutically acceptable solvents and/or excipients, where the effective dose refers to the presence of at least 1000 platelets in every milliliter of skincare stimulant. A method for treating a skin condition selected wrinkles, amyloidosis and keratosis pilaris includes spraying or spreading the skincare stimulant having over a body area, where the skincare stimulant is a solution having a concentration of 1000-10000 platelets per milliliter of the solution, wherein a source of the platelets is a platelet dry powder having less than 30% of plasma protein, based on the weight of the platelet dry powder.

The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.

The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides plasma or platelet-rich plasma alone or in cell combinations preparations for use in tissue regeneration and bone regeneration and pain reduction.

The present invention provides a method for re-growing hair in patients with androgenic alopecia by administering effective consecutive courses of Granulocyte-Colony Stimulating Factor or derivatives. After the state of re-growth is obtained, the hair growth is maintained by administering periodic courses of Granulocyte-Colony Stimulating Factor or derivatives. The invention further provides a method for increasing cuticle growth and density using a similar administration of effective consecutive courses of Granulocyte-Colony Stimulating Factor or derivatives. The increased cuticle growth and density is maintained by administering periodic courses of Granulocyte-Colony Stimulating Factor or derivatives.

The present invention relates to a composition for hair regeneration comprising a macrophage-derived extracellular vesicle mimetics, and since macrophage-derived extracellular vesicle mimetics are well absorbed into dermal papilla cells, have an excellent effect in promoting the proliferation of dermal papilla cells, as well as having an activity to increase the level of hair-induced proteins, it is excellent in the effects of proliferation of dermal papilla cells and hair increase and thus a composition comprising macrophage-derived extracellular vesicle mimetics can be provided for hair regeneration.

A method of isolating a high number of exosome extracts with high-activity from animal-derived cord blood or fetal animal or animal milk or other animal-derived body fluids to allow high-activity exosome-liposome hybridization is provided. The method is performed as follows: the animal cord blood is transferred into a tube/blood bag containing 1-3% Anticoagulant and shaken in reverse at a 90-degree angle gently, then the blood sample is transferred into a large cylindrical chamber, and is pushed repeatedly through an air-tight chamber with medical grade glass beads to achieve emulsification, at least 1 time per second for at least 20 repetitions. The plasma of the blood obtained in the above step is centrifuged at 2,000-3,000 G/min for 2-6 minutes to obtain 2 phases, the plasma fragment containing large and small proteins and exosomes is separated, and the exosomes in the plasma fragment are isolated by using a polymer-based precipitation method.

This invention relates to the field of dermatology and cosmetology and describes methods of using small molecule chemical compounds and formulations thereof to reduce the appearance of rhytids and wrinkles. These methods and formulations are contemplated for cosmetic uses of reducing the appearance of rhytids or wrinkles, or for potential therapeutic uses of reducing, reversing, or treating rhytids or wrinkles. Also contemplated are use of these compounds to reduce the appearance of rhytids or wrinkles or for potential therapeutic uses of reducing, reversing, or treating rhytids or wrinkles.