The present invention relates to an improved gelatinous coated dosage form having two end regions coated with gelatinous materials and an exposed circumferential band. Openings are provided in at least the exposed band to reveal the core material. The invention also relates to methods for manufacturing such gelatinous coated dosage forms.

The present invention relates to a pharmaceutical composition comprising pancreatin, which has a coating that contains a least one lipase. Preferably the at least one lipase is burlulipase. It also relates to a medicinal product comprising such a pharmaceutical composition. A method of producing such a pharmaceutical composition also forms part of the present invention.

A dosage form comprising a tablet core and one or more discontinuous coated regions in various configurations on the surface of the dosage form is disclosed. A method for making the dosage form is also disclosed.

This invention provides a method of colonic cleansing.

The invention provides a drug delivery system in which a drug or another active substance is delivered from the surface of an inactive, placebo carrier. The system uses a placebo tablet carrier having a concavity or multiple concavities in the top surface for receiving a drug. After manufacture of the placebo tablet carrier, a dosage of the drug in liquid or semisolid form is deposited in the concavity and solidifies as a dot or disk on the tablet surface. Thus, the drug is carried on the surface of the tablet and is not part of the tablet bulk. The drug delivery system is particularly useful for delivery of low dose (i.e. potent) drugs, for delivery of multiple doses of a drug, or for delivery of multiple types of drugs. Additionally, the invention provides methods for preparation of the inventive drug delivery systems.

An ingestible pill is provided that includes an enteric coating and a medication-delivery device, which includes (a) a patch having upper and lower surfaces that face in generally opposite directions, and (b) needles. The patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least 50% of the needles are coupled to the patch along the inner crease sides. The patch is configured to assume, after the enteric coating dissolves, an expanded shape, in which the patch has an outer perimeter. Other embodiments are also described.

The present disclosure is directed to compositions and methods for the production of a fast dissolving tablets to be used for the delivery of an agent. An agent can be an active pharmaceutical agent or a non-pharmacological agent, which is needed to be delivered by means of a fast dissolving delivery system. The invention solves many industry challenges within the field of fast dissolve technologies, specifically coupling of fast dissolve properties with required physical attributes of strength/robustness required for commercial production and distribution.

A consumable macromolecular article of manufacture formed by the complexation of protein and polysaccharide polymers stabilized by chemical crosslinking and subsequently cast and molded into macrocapsules of at least 1 mm in diameter. The resulting macrocapsules are a highly versatile delivery product capable of encapsulating and stably retaining a wide range of active ingredients, both liquids and solids, in the amorphous regions of the complexed and crosslinked macromolecular structure, and releasing such active ingredients only upon chewing and/or upon exposure to the digestive environment. Dissimilar layers may be utilized to combine multiple active ingredients and/or control the active ingredient release profiles. The article of manufacture is thermally stable and structurally robust providing relatively low-cost commercial manufacture and distribution and exhibiting a texture and consistency that is organolepically pleasing.

Provided in the present invention are a new use of thiopeptin in the preparation of drugs for treating diseases caused by clostridium difficileinfections and complications thereof, and pharmaceutical preparations containing the thiopeptin for treating diseases caused by clostridium difficileinfections and complications thereof.

This invention provides a method of colonic cleansing.