The present invention includes substituted 1,1′-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

##STR00001##

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

##STR00001##

The present invention relates to processes for preparing substances with antiviral activity, in particular the integrase inhibitors dolutegravir and cabotegravir and analogues thereof, as well as intermediates useful in the processes.

The present invention relates to processes for preparing substances with antiviral activity, in particular the integrase inhibitors dolutegravir and cabotegravir and analogues thereof, as well as intermediates useful in the processes.

The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them,

##STR00001##

wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, Y, R.sup.2 and R.sup.7 are as defined herein,

and methods for producing such compounds.

The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them,

##STR00001##

wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, Y, R.sup.2 and R.sup.7 are as defined herein,

and methods for producing such compounds.

Provided herein are combination therapies for the treatment of pathological conditions, such as cancer, using MEK antagonists.

Provided herein are combination therapies for the treatment of pathological conditions, such as cancer, using MEK antagonists.

A method for preventing, slowing, or blocking the formation of an exostosis or an enchondromas comprising administering to an animal in need thereof a hedgehog pathway inhibitor such as a Smoothened inhibitor.