Compositions for treating a sleep disorder or modifying or improving the sleep-wake cycle in a subject are disclosed herein. In some examples, the composition can comprise one or more sleep promoting active agents, one or more sleep quality active agents, one or more sleep recovery active agents, and optionally one or more next day active agents. The composition can provide an immediate burst release of the one or more sleep promoting active agents, a delayed burst or delayed sustained release of the one or more sleep quality active agents, a delayed burst or delayed sustained release of the one or more sleep recovery active agents, and a delayed burnt or delayed sustained release of the one or more next day active agents. The composition can be provided as a daily oral uni-dosage form. Methods of making and using the compositions are also provided.

A product comprising theanine, caffeine, and CBD is disclosed. Alternatives to the specific components are also described. A product comprising theanine, pyridoxine triacetate, and CBD is also disclosed. Alternatives to the specific components are also described. In an embodiment, an oral thin film strip delivery system includes a polymer, muco-adhesive, or other component that allows the product to dissolve in the mouth.

A product comprising theanine, caffeine, and CBD is disclosed. Alternatives to the specific components are also described. A product comprising theanine, pyridoxine triacetate, and CBD is also disclosed. Alternatives to the specific components are also described. In an embodiment, an oral thin film strip delivery system includes a polymer, muco-adhesive, or other component that allows the product to dissolve in the mouth.

A product comprising theanine, caffeine, and CBD is disclosed. Alternatives to the specific components are also described. A product comprising theanine, pyridoxine triacetate, and CBD is also disclosed. Alternatives to the specific components are also described. In an embodiment, an oral thin film strip delivery system includes a polymer, muco-adhesive, or other component that allows the product to dissolve in the mouth.

Vitamin B1 deficiency caused when a pyridoxamine compound is administered in a large amount is prevented and/or treated. A pharmaceutical composition formed by combining at least one pyridoxamine compound selected from the group consisting of pyridoxamine and pharmaceutically acceptable salts thereof and at least one thiamine compound selected from the group consisting of thiamine, derivatives thereof, and pharmaceutically acceptable salts thereof, is administered.

Vitamin B1 deficiency caused when a pyridoxamine compound is administered in a large amount is prevented and/or treated. A pharmaceutical composition formed by combining at least one pyridoxamine compound selected from the group consisting of pyridoxamine and pharmaceutically acceptable salts thereof and at least one thiamine compound selected from the group consisting of thiamine, derivatives thereof, and pharmaceutically acceptable salts thereof, is administered.

Vitamin B1 deficiency caused when a pyridoxamine compound is administered in a large amount is prevented and/or treated. A pharmaceutical composition formed by combining at least one pyridoxamine compound selected from the group consisting of pyridoxamine and pharmaceutically acceptable salts thereof and at least one thiamine compound selected from the group consisting of thiamine, derivatives thereof, and pharmaceutically acceptable salts thereof, is administered.

Compositions and methods for increasing absorption of nutrients by a body. A composition includes a liposome comprising a lipid bilayer, wherein the liposome comprises an internal core. The composition includes a nutrient payload disposed within the liposome. The nutrient payload comprises a plurality of different supplement nutrients comprising one or more of a vitamin, mineral, extract, enzyme, or amino acid.

Compositions and methods for increasing absorption of nutrients by a body. A composition includes a liposome comprising a lipid bilayer, wherein the liposome comprises an internal core. The composition includes a nutrient payload disposed within the liposome. The nutrient payload comprises a plurality of different supplement nutrients comprising one or more of a vitamin, mineral, extract, enzyme, or amino acid.

A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid, a nitric oxide releasing compound, Vitamin B12 and choline. The composition is administered in a daily dose that provides 0.1 to 50 times the recommended daily requirement (RDA) of Vitamin B12 per day, more preferably 0.1 to 40 times the recommended daily requirement (RDA) of Vitamin B12 per day and 0.01 to 10.0 times the recommended daily requirement (RDA) of choline. Optionally Vitamin B6 and/or Vitamin B9 can be included in the composition. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human.