Provided herein is a pharmaceutical composition comprising two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H.sub.1-receptor agonist, a histamine H.sub.2-receptor agonist, a histamine H.sub.3-receptor antagonist, or a β.sub.2-adrenoreceptor agonist. Also provided herein is a method of treating, preventing, or ameliorating a cardiovascular disease in a subject, comprising administering to the subject in need thereof two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H.sub.1-receptor agonist, a histamine H.sub.2-receptor agonist, a histamine H.sub.3-receptor antagonist, or a β.sub.2-adrenoreceptor agonist.

Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.

Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.

Methods for treating Gaucher disease in patients with renal or hepatic impairment.

Methods for treating Gaucher disease in patients with renal or hepatic impairment.

Methods for treating Gaucher disease in patients with renal or hepatic impairment.

A method is provided to prevent and to treat gingival recession by using Calcium Channel Blockers, Angiotensin-Converting Enzyme (ACE) Inhibitors, or Angiotensin Receptor Blockers (ARB), and more particularly, to a method to prevent and treat gingival recession, e.g., age related gingival recession, by using Calcium Channel Blockers, Angiotensin-Converting Enzyme Inhibitors, or Angiotensin Receptor Blockers that are not taken orally, but administered by injection into the affected tissue or administered by topical application to the tissue of the gum, so as to increase the capillary network and blood supply to the cartilage, bones, ligaments, and soft tissues.

A method is provided to prevent and to treat gingival recession by using Calcium Channel Blockers, Angiotensin-Converting Enzyme (ACE) Inhibitors, or Angiotensin Receptor Blockers (ARB), and more particularly, to a method to prevent and treat gingival recession, e.g., age related gingival recession, by using Calcium Channel Blockers, Angiotensin-Converting Enzyme Inhibitors, or Angiotensin Receptor Blockers that are not taken orally, but administered by injection into the affected tissue or administered by topical application to the tissue of the gum, so as to increase the capillary network and blood supply to the cartilage, bones, ligaments, and soft tissues.

A method is provided to prevent and to treat hearing loss by using Calcium Channel Blockers, Angiotensin-Converting Enzyme (ACE) Inhibitors, or Angiotensin Receptor Blockers (ARB), and more particularly, to a method to prevent and treat hearing loss by using Calcium Channel Blockers, Angiotensin-Converting Enzyme Inhibitors, or Angiotensin Receptor Blockers that are not taken orally, but administered topically or by injection, so as to increase the capillary network and blood supply to the affected tissues, e.g., through to the external ear space and/or the middle ear space and/or the inner ear space to form contact with the ear hearing apparatus.

A method is provided to prevent and to treat hearing loss by using Calcium Channel Blockers, Angiotensin-Converting Enzyme (ACE) Inhibitors, or Angiotensin Receptor Blockers (ARB), and more particularly, to a method to prevent and treat hearing loss by using Calcium Channel Blockers, Angiotensin-Converting Enzyme Inhibitors, or Angiotensin Receptor Blockers that are not taken orally, but administered topically or by injection, so as to increase the capillary network and blood supply to the affected tissues, e.g., through to the external ear space and/or the middle ear space and/or the inner ear space to form contact with the ear hearing apparatus.