Provided is a topical pharmaceutical gel composition of an amlodipine salt and methods for its use in the treatment of anorectal disease.

Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.

Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.

The present invention concerns a compound inhibitor of the initiation step of the reverse transcription of RNA of a type 1 human immunodeficiency virus (HIV-1) for use in a method for treating a type 1 human immunodeficiency virus (HIV-1).

The present invention concerns a compound inhibitor of the initiation step of the reverse transcription of RNA of a type 1 human immunodeficiency virus (HIV-1) for use in a method for treating a type 1 human immunodeficiency virus (HIV-1).

The present disclosure relates to a combination including an outer container for mounting in a container holder of a planetary mixer, the outer container receiving an inner container arrangement allowing to mix ingredients into the inner container arrangement with the planetary mixer to produce in the inner container arrangement a pharmaceutical composition. The outer container may include a body having an outer wall and an inner wall. The inner wall may delimit a central cavity for nestably receiving the inner container arrangement. The outer container may also include a slot on the inner wall. The slot may engage with a protrusion on the inner container arrangement when the inner container arrangement is received in the central cavity to inhibit rotational motion of the inner container arrangement within the outer container, induced as a result of combined rotation and revolution imparted to the outer container by the planetary mixer.

The present disclosure relates to a combination including an outer container for mounting in a container holder of a planetary mixer, the outer container receiving an inner container arrangement allowing to mix ingredients into the inner container arrangement with the planetary mixer to produce in the inner container arrangement a pharmaceutical composition. The outer container may include a body having an outer wall and an inner wall. The inner wall may delimit a central cavity for nestably receiving the inner container arrangement. The outer container may also include a slot on the inner wall. The slot may engage with a protrusion on the inner container arrangement when the inner container arrangement is received in the central cavity to inhibit rotational motion of the inner container arrangement within the outer container, induced as a result of combined rotation and revolution imparted to the outer container by the planetary mixer.

The present disclosure relates to a combination including an outer container for mounting in a container holder of a planetary mixer, the outer container receiving an inner container arrangement allowing to mix ingredients into the inner container arrangement with the planetary mixer to produce in the inner container arrangement a pharmaceutical composition. The outer container may include a body having an outer wall and an inner wall. The inner wall may delimit a central cavity for nestably receiving the inner container arrangement. The outer container may also include a slot on the inner wall. The slot may engage with a protrusion on the inner container arrangement when the inner container arrangement is received in the central cavity to inhibit rotational motion of the inner container arrangement within the outer container, induced as a result of combined rotation and revolution imparted to the outer container by the planetary mixer.

Provided herein are stable amlodipine oral liquid formulations. Also provided herein are methods of using amlodipine oral liquid formulations for the treatment of certain diseases including hypertension and Coronary Artery Disease (CAD).

Provided herein are stable amlodipine oral liquid formulations. Also provided herein are methods of using amlodipine oral liquid formulations for the treatment of certain diseases including hypertension and Coronary Artery Disease (CAD).