A method for regulating an expression level of Musashi1 in cells. In particular, the present application relates to a cell-regulating composition capable of regulating the expression or activity, in cells, of any one selected from the followings: K19, α2β1 integrin, and Musashi1. The regulating composition can promote proliferation, growth, and migration of epidermal cells, promote proliferation, growth, and migration of vascular endothelial cells, and promote proliferation, growth, and migration of fibroblasts.

A method for regulating an expression level of Musashi1 in cells. In particular, the present application relates to a cell-regulating composition capable of regulating the expression or activity, in cells, of any one selected from the followings: K19, α2β1 integrin, and Musashi1. The regulating composition can promote proliferation, growth, and migration of epidermal cells, promote proliferation, growth, and migration of vascular endothelial cells, and promote proliferation, growth, and migration of fibroblasts.

The present disclosure provides compositions and formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults, especially adult women, and for prevention of age associated neurodegenerative changes resulting in cognitive, memory and executive dysfunction including modulation of the age related predisposition to mild cognitive impairment, Alzheimer's disease, hormonal and other dementia related conditions. The present disclosure also provides methods of using the compositions and formulations in treating and preventing neurodegenerative changes resulting in cognitive, memory and executive dysfunction.

The present disclosure provides compositions and formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults, especially adult women, and for prevention of age associated neurodegenerative changes resulting in cognitive, memory and executive dysfunction including modulation of the age related predisposition to mild cognitive impairment, Alzheimer's disease, hormonal and other dementia related conditions. The present disclosure also provides methods of using the compositions and formulations in treating and preventing neurodegenerative changes resulting in cognitive, memory and executive dysfunction.

The present disclosure provides compositions and formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults, especially adult women, and for prevention of age associated neurodegenerative changes resulting in cognitive, memory and executive dysfunction including modulation of the age related predisposition to mild cognitive impairment, Alzheimer's disease, hormonal and other dementia related conditions. The present disclosure also provides methods of using the compositions and formulations in treating and preventing neurodegenerative changes resulting in cognitive, memory and executive dysfunction.

Provided are methods for treating inflammation in subject in need thereof. In some embodiments, the methods include administering to the subject an effective amount of a Sigma-1 receptor (S1R) activity modulator to thereby treat inflammation in the subject. Also provided are pharmaceutical compositions that include an effective amount of a Sigma-1 receptor (S1R) activity modulator and uses of the pharmaceutical compositions to treat inflammation in a subject in need thereof.

Provided are methods for treating inflammation in subject in need thereof. In some embodiments, the methods include administering to the subject an effective amount of a Sigma-1 receptor (S1R) activity modulator to thereby treat inflammation in the subject. Also provided are pharmaceutical compositions that include an effective amount of a Sigma-1 receptor (S1R) activity modulator and uses of the pharmaceutical compositions to treat inflammation in a subject in need thereof.

A composition-of-matter is provided. The present composition includes dietary supplements capable of reducing or reversing the negative effects of alcohol on motor and cognition, dietary supplements having anti-gastroparesis, antiemetic, analgesic and anti-inflammatory activities and/or dietary supplements capable of increasing alcohol catabolism and decreasing the level of toxic products of alcohol catabolism.

A composition-of-matter is provided. The present composition includes dietary supplements capable of reducing or reversing the negative effects of alcohol on motor and cognition, dietary supplements having anti-gastroparesis, antiemetic, analgesic and anti-inflammatory activities and/or dietary supplements capable of increasing alcohol catabolism and decreasing the level of toxic products of alcohol catabolism.

A composition-of-matter is provided. The present composition includes dietary supplements capable of reducing or reversing the negative effects of alcohol on motor and cognition, dietary supplements having anti-gastroparesis, antiemetic, analgesic and anti-inflammatory activities and/or dietary supplements capable of increasing alcohol catabolism and decreasing the level of toxic products of alcohol catabolism.