Patent classifications
A61K31/529
Cyclic Pyridine Derivatives as cGAS Inhibitors
The invention relates to compounds of formula I
##STR00001##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A, D, E, G, J, K and L are defined as in claim 1, and prodrugs, deuterated analogues and pharmaceutical acceptable salts thereof, for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
Cyclic Pyridine Derivatives as cGAS Inhibitors
The invention relates to compounds of formula I
##STR00001##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A, D, E, G, J, K and L are defined as in claim 1, and prodrugs, deuterated analogues and pharmaceutical acceptable salts thereof, for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
MACROCYCLIC COMPOUNDS AS ROS1 KINASE INHIBITORS
Methods for inhibiting a ROS1 kinase with compounds of Formula I:
##STR00001##
and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R.sup.2, R.sup.2a, R.sup.3, R.sup.3a, and Z are as defined herein. The compounds and methods provided herein are useful in the treatment of cancer (e.g., ROS1-associated cancers as defined herein).
MACROCYCLIC COMPOUNDS AS ROS1 KINASE INHIBITORS
Methods for inhibiting a ROS1 kinase with compounds of Formula I:
##STR00001##
and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R.sup.2, R.sup.2a, R.sup.3, R.sup.3a, and Z are as defined herein. The compounds and methods provided herein are useful in the treatment of cancer (e.g., ROS1-associated cancers as defined herein).
Highly Active Anti-Neoplastic and Anti-Proliferative Agents
This invention is in the area of improved compounds and methods for treating selected cancers and hyperproliferative disorders.
Highly Active Anti-Neoplastic and Anti-Proliferative Agents
This invention is in the area of improved compounds and methods for treating selected cancers and hyperproliferative disorders.
Methods for treating hair loss disorders
The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
Methods for treating hair loss disorders
The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
SUBSTITUTED 2,3,4,5,7,9,13,13A-OCTAHYDRO-1,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[1,3]DIAZEPINES AND METHODS FOR TREATING VIRAL INFECTIONS
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):
##STR00001##
including stereoisomers and pharmaceutically acceptable salts thereof, wherein R.sup.1, X, W, Y.sup.1, Y.sup.2, Z.sup.1, and Z.sup.4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
SUBSTITUTED 2,3,4,5,7,9,13,13A-OCTAHYDRO-1,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[1,3]DIAZEPINES AND METHODS FOR TREATING VIRAL INFECTIONS
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):
##STR00001##
including stereoisomers and pharmaceutically acceptable salts thereof, wherein R.sup.1, X, W, Y.sup.1, Y.sup.2, Z.sup.1, and Z.sup.4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.