Compositions which include polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus or amino terminus of an insulin-like growth factor 1 (IGF-1) or IGF-1 variant. Polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

Disclosed herein are methods of treating hair loss affected areas. In some embodiments, the methods of treating hair loss comprise delivering senescent cells or factors derived from senescent cells to the hair loss effected area. Also disclosed herein are methods of making compositions of senescent cells and compositions of senescent cells.

In one embodiment, a method includes accessing steady-state operational parameters for each of a plurality of network nodes of the multi-hop wireless network recorded during a period of steady-state operation, identifying a plurality of first network nodes and a plurality of second network nodes, wherein each of the first network nodes is determined to need a planned reset, and wherein each of the second network nodes previously established one or more wireless connections with one or more of the first network nodes, respectively, adjusting operational settings of each of the second network nodes to establish one or more temporary wireless connections between one or more pairs of second networks nodes, respectively, resetting each of the first network nodes, adjusting operational settings of each of the second network nodes based on the steady-state operational parameters to reestablish the one or more previously established wireless connections with the first network nodes.

In one embodiment, one or more computing systems of a multi-hop wireless network may access operational parameters for network nodes of the multi-hop wireless network, wherein the multi-hop wireless network comprises a plurality of network nodes, wherein each network node of the plurality of network nodes previously established one or more wireless connections with one or more corresponding network nodes, respectively, and wherein the operational parameters are based on operating data recorded during a period of steady-state operation of the multi-hop wireless network. The one or more computing systems may identify one or more responder nodes from the plurality of network nodes, wherein, for each identified responder node, one or more of the previously established wireless connections has been reset. The one or more computing systems may adjust operational settings for each responder node based on the accessed operational parameters.

It is an object of the present invention to provide methods and compositions for protection of subjects from acute kidney injury by treating the subject with compounds that modulate the cell cycle. Modulating the cell cycle can comprise inducing G.sub.0/G.sub.1 cell cycle arrest, and/or inducing cell cycle progression. As demonstrated below, even a single administration of a compound which induces G.sub.0/G.sub.1 cell cycle arrest can protect subjects from AKI, and may be used prophylactically in advance of, or as a treatment following, various treatments or conditions that are known to be injurious to the kidney, followed optionally by release of the arrest. Once AKI is established, cell cycle progression can be induced to increase replacement of lost and damaged cells.

A non-immunogenic two-part clotting composition derived from human umbilical cords and methods of making thereof. The non-immunogenic two-part clotting composition may be used for dental purposes (periodontic and/or endodontic purposes) such as packing a subject's gum post-tooth extraction and/or for other wound packing purposes.

A non-immunogenic two-part clotting composition derived from human umbilical cords and methods of making thereof. The non-immunogenic two-part clotting composition may be used for dental purposes (periodontic and/or endodontic purposes) such as packing a subject's gum post-tooth extraction and/or for other wound packing purposes.

Provided herein are new compositions and methods to target pharmaceutical agents to pathological areas by utilizing bifunctional fusion polymers or nanoparticles. These fusion polymers and nanoparticles contain two or more domains: (i) sequences that bind to exposed collagenous (XC-) proteins present in pathological areas, including cancerous lesions and (ii) domains that bind to pharmaceutical agents. The drug-binding functionality of these fusion polymers and nanoparticles is based on high-affinity, non-covalent interactions.

Provided herein are new compositions and methods to target pharmaceutical agents to pathological areas by utilizing bifunctional fusion polymers or nanoparticles. These fusion polymers and nanoparticles contain two or more domains: (i) sequences that bind to exposed collagenous (XC-) proteins present in pathological areas, including cancerous lesions and (ii) domains that bind to pharmaceutical agents. The drug-binding functionality of these fusion polymers and nanoparticles is based on high-affinity, non-covalent interactions.

The present technology generally relates to compounds, in particular peptides comprising the heparin-binding domain (HBD) of insulin-like growth factor binding protein-2 (IGFBP-2) for the modulation of metabolic disorders. The present technology also generally relates to uses of such compounds in methods for preventing and/or treating metabolic disorders and in compositions and formulations for such uses.