The present invention has revealed that an antiviral agent containing a serine protease such as subtilisin, nattokinase, and trypsin has an effect of inactivating non-envelope type viruses, and that combining such an antiviral agent containing a serine protease with a cationic polymer enhances the inactivation effect of the antiviral agent against non-envelope type viruses. As a result, an antiviral agent that is highly safe, that has a high virus inactivation ability, and that contains a component that is inexpensive in terms the manufacturing cost and a cationic polymer, was discovered.

Provided herein, in some aspects, are compositions comprising vasoocclusion-inhibiting agents encapsulated in RBCs and uses thereof for treating blood vessel occlusion (e.g., in Sickle Cell Disease).

The present invention provides compositions and methods for regulating pancreatic beta cell function through modulation of adipsin activity and/or expression. Also provided are methods for preventing, treating, diagnosing, and prognosing metabolic disorders, such as diabetes, in a subject through modulation or detection of adipsin activity and/or expression.

The methods and uses described herein relate to the modulation of the immune system by modulation of Sema3F levels and/or activity, e.g. suppressing allograft rejection or inflammation by administering a Sema3F agonist or increasing an immune response by administering a Sema3F inhibitor.

The application disclosure provides a sterically stabilized liposome carrier encapsulating a selected drug for the aerosol delivery of the drug effectual in the treatment of a mammal, a composition containing the sterically stabilized liposome carrier and the selected drug effective for the treatment of airway hypersensitivity and inflammation such as of the lungs of a mammal as an aerosol, and a method of treatment using the composition. The composition disclosed herein provides effective treatment for the longer of a period of time at least twice as long as the selected drug alone or up to at least one week.

Disclosed are methods and related compositions for administering an immunoglobulin (Ig) protease in combination with synthetic nanocarriers comprising immunosuppressants. The methods and compositions provided can be used for treating Ig deposition diseases and disorders, such as IgA nephropathy.

This invention relates to methods of treatment for arthritis using SPL-108 polypeptide. In particular, this invention relates to such methods of treatment by the administration of an SPL-108 polypeptide (also known as A6 peptide, a CD44 modulating peptide) or a variant thereof alone or in combination with a standard-of-care treatment for arthritis to alleviate and/or prevent symptoms of arthritis and/or to avoid side effects commonly associated with treating arthritis. Such methods of the present invention are used to treat inflammatory conditions such as rheumatoid arthritis, osteoarthritis, reactive arthritis, and/or psoriatic arthritis.

This invention relates to methods of treatment for arthritis using SPL-108 polypeptide. In particular, this invention relates to such methods of treatment by the administration of an SPL-108 polypeptide (also known as A6 peptide, a CD44 modulating peptide) or a variant thereof alone or in combination with a standard-of-care treatment for arthritis to alleviate and/or prevent symptoms of arthritis and/or to avoid side effects commonly associated with treating arthritis. Such methods of the present invention are used to treat inflammatory conditions such as rheumatoid arthritis, osteoarthritis, reactive arthritis, and/or psoriatic arthritis.

Disclosed are compositions comprising one or more enzymes capable of catalysing the hydrolysis of keratinocyte effector molecules such as protein keratins that support the function and integrity of the human skin and its appendages such as the hair follicle that are supported by keratinocytes to maintain the biological barrier, function and struture. The compositions are useful in treating follicular dermatoses and hair follicle-linked conditions, such as Hirsutism and Hidradenitis suppurativa. The compositions may also be used to loosen hair from the skin and thereby be used for removing undesired hair from the human body.

Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.