The present disclosure provides a lipid nanoparticle comprising: a nucleic acid cargo molecule; sterol or a derivative thereof present at elevated content; neutral lipid; an ionizable lipid; and a hydrophilic polymer-lipid conjugate present at a content between 0.5 and 3 mol %, wherein each mol % content is relative to total lipid present in the lipid nanoparticle.

A compound including a general formula of D-L-A particularly with the structure of Formula (A). A nanoparticle of the compound of the present invention. A pharmaceutical composition including the compound of the present invention as an active ingredient and a pharmaceutically acceptable carrier. A method of treating a target tissue including administering to a patient in need thereof a compound of the present invention and administering to the target tissue radiation in an amount and of a wavelength effective to activate the compound. Also use of the compound of the present invention in preparation of a medicament for treating the target tissue by photodynamic therapy.

Provided herein are therapeutic peptides. In some aspects, therapeutic peptides are provided that can alter EphB4/EFNB2 signaling and can be used to treat a cancer. In some embodiments, the peptides are comprised in nanoparticles, such as core-cross-linked polymeric micelles (CCPM).

Disclosed are compounds and compositions that preferentially target cancer cells with a warhead that comprises a chemotherapeutic agent releasably bound to a targeting agent where the chemotherapeutic agent is released upon cellular absorption. Also disclosed are methods of use.

Disclosed are compounds and compositions that preferentially target cancer cells with a warhead that comprises paclitaxel releasably bound to a targeting agent where the chemotherapeutic agent is released upon cellular absorption. Also disclosed are methods of use.

A drug delivery system includes a plurality of nanoparticles wherein each nanoparticle includes a targeting peptide conjugated thereto that targets atherosclerotic plaque and a therapeutic agent conjugated thereto for treating atherosclerotic plaque. Alternatively, a drug delivery system includes a plurality of micelles wherein each micelle includes a targeting peptide conjugated thereto that targets atherosclerotic plaque and a drug incorporated into the core of the micelle or conjugated to the hydrophobic tail of the amphiphiles. A method for treating atherosclerosis in a subject is also provided.

The present invention refers to polymeric reverse micelles for delivery of hydrophilic macromolecules. In particular, it relates to a polymeric reverse micelle for the delivery of an active pharmaceutical ingredient, wherein the interior of the reverse micelle is hydrophilic and is suitable to contain a water-soluble active pharmaceutical ingredient and the exterior of the reverse micelle is hydrophobic, wherein said reverse micelle comprises at least two polymers, each one having the formula (I) disclosed in the description. A process to obtain such reverse micelle is also an object of the invention such as pharmaceutical compositions comprising the micelle.

Only limited success has been previously achieved from cancer vaccines targeting unmodified tumor-associated self-antigens and new compositions and methods are needed. Immunogenic compositions and methods of use thereof are provided according to the present disclosure which include a protein effective to stimulate immune activity against a tumor-associated self-antigen, or a variant thereof which is a tumor-associated self-antigen.