A toothpaste and toothbrush holder device for storing and dispensing toothpaste includes a box that has a toothbrush chamber and a toothpaste chamber for storing a toothbrush and a tube of toothpaste. A pair of doors is each of the pair of doors is hingedly coupled to the box for opening or closing a respective toothbrush chamber or toothpaste chamber. A dispensing unit is movably integrated into the box and the dispensing unit is positioned in the toothpaste chamber to facilitate the dispensing unit to engage the tube of toothpaste. The dispensing unit is actuatable in a dispensing condition to urge toothpaste to flow outwardly from the tube of toothpaste.