An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle with a plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.

A device for extracorporeal blood circulation includes a potted body having an oxygenator module including at least two of a plurality of circular hollow fiber mat layers, a heat exchanger module including at least two of the plurality of circular hollow fiber mat layers, a blood inlet port adjacent a first end of the potted body and a blood outlet port adjacent a second end of the potted body. The device includes a gas inlet and outlet port and a fluid inlet and outlet port. A first of the plurality of hollow fiber mats includes a plurality of hollow fibers aligned in a direction that is angled relative to a direction of alignment of the plurality of hollow fibers of a second of the plurality of hollow fiber mats and, the plurality of hollow fiber mats are aligned to have the same orientation as one another.

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

An oxygenator and method for oxygenating blood. The oxygenator includes a housing, an oxygenation chamber, and elongated gas permeable conduits that extend across the oxygenation chamber. The blood flow enters and contacts with exterior surfaces of the conduits and exits the oxygenator to transfer of oxygen from within the conduits to the blood flow and transfer carbon dioxide from the blood flow into the elongated gas permeable conduits. The housing includes a gas inlet and is configured to distribute a gas flow received through the gas inlet to the elongated gas permeable conduits so as to a first portion of the gas flow flows through a first set of the elongated gas permeable conduits in a first direction and a second portion of the gas flow flows through a second set of the elongated gas permeable conduits in a second direction that is opposite to the first direction.

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

Disclosed is a blood oxygenator. The blood oxygenator includes a blood inlet chamber, and a housing. A hollow cavity is arranged in the housing, and includes a heat exchange zone and a gas exchange zone. Multiple heat exchange filaments are arranged in the heat exchange zone. Multiple hollow fibrous membrane fibers are arranged in the gas exchange zone. The blood inlet chamber includes an inverted conical side wall and an end surface hermetically connected to an opening at one end of the inverted conical side wall, an opening at the other end of the inverted conical side wall is hermetically connected to one end of the housing, and the other end of the housing is hermetically connected with a cover body. The cover body is provided with a blood outlet, and the end surface is provided with a spiral liquid inlet pipe coaxial with the blood inlet chamber.

An extracorporeal system for lung assist includes a housing having a blood flow inlet in fluid connection with a pressurizing stator compartment within the housing. A fiber bundle compartment within the housing is above and in fluid connection with the pressurizing stator compartment via a flow channel formed within the housing and extending from the pressurizing stator compartment to an inlet manifold of the fiber bundle compartment. A blood flow outlet in is fluid connection with an outlet man fold of the fiber bundle compartment. The blood flow inlet extends through the housing parallel to a plane of rotation of an impeller in the pressurizing stator compartment. The blood flow inlet turns to deliver blood into a central portion of the impeller. A has inlet is in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers of a cylindrical fiber bundle positioned within the fiber bundle compartment. A gas outlet is in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.

An extracorporeal system for lung assist includes a system housing, which includes a blood flow inlet and a blood flow outlet and a fiber bundle housing movably positioned within the system housing. The fiber bundle housing includes a gas inlet and a gas outlet. A fiber bundle is in operative connection with the fiber bundle housing. The fiber bundle includes a plurality of hollow gas permeable fibers, wherein lumens of the plurality of hollow gas fibers are in fluid connection with the gas inlet at a first end thereof and in fluid connection with the gas outlet as a second end thereof. The system further includes an actuator to impart oscillatory motion to the fiber bundle housing and thereby to the fiber bundle.

A device for mass transfer between blood and at least one gas/gas mixture, includes first and second chambers through which blood is able to flow and in each of which a respective plurality of mass-permeable hollow fibers are disposed around a respective axially extending core element, wherein a gas/gas mixture is able to flow through, and blood is able to flow around, the hollow fibers, wherein the second chamber follows the first chamber in the blood flow direction, wherein the first and second chambers are disposed next to one another, and in particular disposed spaced apart between the core element center axes thereof, and the two chambers have a connection in an axial end region by which the chamber volumes through which blood is able to flow are connected, and in particular are connected in the direction of the spacing.

A hemodialysis device is described herein. An exemplary hemodialysis device includes an import tube, a dialysis tube, and an export tube. The dialysis tube includes an inner dialysis tube, a dialysis membrane and an outer dialysis tube. The inner dialysis tube is within the dialysis membrane, which is within the outer dialysis tube. An inlet and an outlet of the inner tube are disposed at a first end of the outer dialysis tube. The inlet of the inner dialysis tube is coupled to the import tube and the outlet of the inner dialysis tube is coupled to the export tube. The dialysis tube is inserted into an artery of a patient, and thereby performs hemodialysis within the body. Since the hemodialysis in performed within the artery instead of drawing blood out of the body, the hemodialysis device will minimally affect blood pressure, which is more economic and safe.