A tube mat comprises a plurality of tube portions having a tube longitudinal axis in each case and at least one web portion connecting two tube portions, the tube mat being produced in one piece.

A dialyzer and a fabricating method thereof are provided. The dialyzer includes a housing, a hydrophilic layer, a fixing layer, a plurality of hollow fiber membranes, and two end caps. The housing has a first opening and a second opening, and is provided with a dialysate inlet and a dialysate outlet, wherein an entire peripheral surface of the housing located between the first opening and the dialysate inlet is a first portion, and an entire peripheral surface of the housing located between the second opening and the dialysate outlet is a second portion. The hydrophilic layer is disposed on the inner wall of the first portion and the second portion, wherein the hydrophilic layer and the housing are different materials. The fixing layer is disposed on the hydrophilic layer and fixes the hollow fiber membranes to the inner wall of the housing.

An end cap of a dialyzer and a fabricating method thereof, and a dialyzer are provided. The end cap includes a main body and a sealing element. The main body has a blood port. The sealing element is integrally connected on an inner wall of the main body.

The present disclosure relates to a method and a device for determining an internal filtration rate IFR within a capillary hemodialyzer.

An artificial, extracorporeal system for liver replacement and/or assistance, comprises a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure. The liver dialysis device comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer. The filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.

A filter device (10) for filtration of fluids, in particular for the dialysis of blood. The filter device (10) comprises a housing (12) having a first end (14) and a second end (16) and defining a fluid chamber (18) extending between the first end (14) and the second end (16). The filter device (10) further comprises a first lid (20) provided at the first end (14) of the housing (12) and comprising a first fluid port (22), a first compartment (24), a second compartment (26) and a first internal separating wall (28) separating the first compartment (24) from the second compartment (26). The filter device (10) further comprises a second lid (30) provided at the second end (16) of the housing (12) and comprising a second fluid port (32), a third fluid port (33), a third compartment (34), a fourth compartment (36) and a second internal separating wall (38) separating the third compartment (34) from the fourth compartment (36). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12), wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). The filter device (10) further comprises a first sealing means (42) which separates the fluid chamber (18) from the first and the second compartment (24, 26), the first sealing means (42) having a first longitudinal end facing away from the second lid (30). The filter device (10) further comprises a second sealing means (46) which separates the fluid chamber (18) from the third and the fourth compartment (34, 36), the second sealing means (46) having a second longitudinal end facing away from the first lid (20). Still further, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18) and located between the first longitudinal end of the first sealing means (42) and the second longitudinal end of the second sealing means (46).

A fluid conduit includes a first portion having a first porosity, a second portion disposed immediately adjacent to the first portion, the second portion having a second porosity that is greater than the first porosity, and a third portion of the fluid conduit disposed immediately adjacent to the second portion, the third portion having a third porosity that is less than the second porosity. Each of the first portion, the second portion, and the third portion may be integrally formed as a single, continuous piece defining the fluid conduit.

A method is presented for checking the integrity of a hollow-fibre fluid filter, in particular a hollow-fibre dialyzer (1), which is constructed from a plurality of hollow fibres (15) enclosed by a membrane, with the steps of: perfusing the inside or outside of the hollow fibres (15) with a fluid, supplying the outside or inside of the hollow fibres (15) with a gas, wherein the gas has a higher pressure than the fluid, and determining a quantity of the gas which penetrates into the fluid through holes in the membrane. The method is characterized in that, after flowing through the hollow-fibre fluid filter (1), the fluid is channelled through a bubble trap (30), and in that a volume of gas (41) collecting in the bubble trap (30) during a predefined or predefinable reference period is determined. Furthermore, equipment for checking the integrity of a hollow-fibre fluid filter (1) is presented.

Flexible manifolds configured for use in a wearable artificial kidney are provided and can include an array of manifold plates defining one or more flow path and which are adapted to receive dialysis components including cleaning columns and dialyzers. Wearable artificial kidneys are also provided. For example, a wearable artificial kidney can include a flexible manifold, a first flow path, a second flow path, a third flow path, a first cleaning column, a first dialyzer, a second dialyzer, a second cleaning column, and at least one pump. Systems for performing dialysis are further provided. The systems can include a wearable artificial kidney and manifold inlet and outlet lines for connecting the peritoneum of a dialysis patient to the wearable artificial kidney. Methods for performing dialysis utilizing the flexible manifolds, wearable artificial kidneys, and systems containing the same, are also provided.

A gas supply control system for an oxygenator of an extracorporeal ventilation system is configured for connection to external gas supply ports for oxygen and nitrogen in the form of air and to create a supply gas output from oxygen and nitrogen. The gas supply control system includes two or more gas output lines and configured to supply the two or more gas output lines with the supply gas output. The flow rates through the gas output lines may be modulated differently.