A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

A renal therapy system with cassette-based blood and dialysate pumping is disclosed. An example system includes a blood pump actuator, a dialysis fluid pump actuator, a dialysis fluid heater, a dialyzer, and a disposable unit. The example disposable unit includes a blood cassette portion configured to be operatively connected to the blood pump actuator to pump blood through the blood cassette portion. The example disposable unit also includes a dialysis fluid cassette portion, separate from the blood cassette portion, configured to be operatively connected to the dialysis fluid pump actuator to pump dialysis fluid through the dialysis fluid cassette portion. The blood cassette portion and the dialysis fluid cassette portion are both in fluid communication with the dialyzer. The example disposable unit also includes a heater bag configured to be placed in operable communication with the dialysis fluid heater and in fluid communication with the dialysis fluid cassette portion.

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

The present invention relates to a dialysis machine having a dialyzer and having a first balancing chamber and having a second balancing chamber, wherein the first inflows of the first balancing chamber halves are in fluid communication with a source of fresh dialyzate and the first outflows of the first balancing chamber halves are in fluid communication with a dialyzer inflow, and wherein the second inflows of the second balancing chamber halves are in fluid communication with a dialyzer outflow and the second outflows of the second balancing chamber halves are in fluid communication with a drain, wherein a third balancing chamber is provided that has two balancing chamber halves that are separated from one another by a movable wall, wherein each of the balancing chamber halves has a respective inflow and a respective outflow that are each provided with valves that are configured to close or open the respective inflow or outflow, wherein the two inflows are in fluid communication with a source of fresh dialyzate, and wherein the two outflows are in fluid communication with the dialyzer inflow.

A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.

A device for extracorporeal blood treatment includes a balancing system and calculates an ultrafiltration volume (UF.sub.D) as a volume withdrawal on the basis of a pressure difference (.sub.P) and a temperature difference (.sub.T) at an inlet and an outlet of at least two balance chambers. To this end, pressure sensors are arranged directly behind an inlet and an outlet of the at least two balance chambers, respectively, and determine a fluid pressure at their respective position, and temperature sensors are arranged at inputs of the at least two balance chambers and determine a temperature in the inlet and the outlet of the balance chamber. The ultrafiltration volume (UD.sub.F) is calculated using the pressure difference (.sub.P) established on the basis of fluid pressure values determined by the pressure sensors, and the temperature difference (.sub.T) established on the basis of temperature values determined by the temperature sensors.

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

A renal therapy system with cassette-based blood and dialysate pumping is disclosed. An example system includes a blood pump actuator, a dialysis fluid pump actuator, a dialysis fluid heater, a dialyzer, and a disposable unit. The example disposable unit includes a blood cassette portion configured to be operatively connected to the blood pump actuator to pump blood through the blood cassette portion. The example disposable unit also includes a dialysis fluid cassette portion, separate from the blood cassette portion, configured to be operatively connected to the dialysis fluid pump actuator to pump dialysis fluid through the dialysis fluid cassette portion. The blood cassette portion and the dialysis fluid cassette portion are both in fluid communication with the dialyzer. The example disposable unit also includes a heater bag configured to be placed in operable communication with the dialysis fluid heater and in fluid communication with the dialysis fluid cassette portion.