A blood purification apparatus is provided in which waste liquid is prevented from flowing through an ultrafiltration pump during ultrafiltration so that the performance and accuracy of ultrafiltration can be maintained over a long period. The blood purification apparatus includes an ultrafiltration line one end of which is connected to a dialysate introduction line at a position on a downstream side with respect to a duplex pump. The ultrafiltration line is provided with the ultrafiltration pump. The ultrafiltration pump is capable of performing ultrafiltration by drawing dialysate in the dialysate introduction line through the ultrafiltration line such that the volume of the dialysate to be introduced into a dialyzer becomes smaller than the volume of waste liquid to be drained from the dialyzer.

A reciprocation pump has a supply liquid-side sub-pumping chamber and a waste liquid side sub-pumping chamber for containing and sending out liquid adapted to communicate with the supply liquid-side pumping chamber and with the waste liquid-side pumping chamber, respectively. The supply liquid-side sub-pumping chamber and the waste liquid-side sub-pumping chamber are interlocked with a reciprocation mechanism to vary their volume reversely to that of the volume variation of the supply liquid-side pumping chamber and the waste liquid-side pumping chamber, respectively. The reciprocating motion of the reciprocation mechanism enables the liquid to be supplied to the objective apparatus through the supply liquid-side pumping chamber and the supply liquid-side sub-pumping chamber. Also, it enables the waste liquid from the objective apparatus to be discharged to the outside through the waste liquid-side pumping chamber and the waste liquid-side sub-pumping chamber.

A blood purification apparatus is provided in which waste liquid is prevented from flowing through an ultrafiltration pump during ultrafiltration so that the performance and accuracy of ultrafiltration can be maintained over a long period. The blood purification apparatus includes an ultrafiltration line one end of which is connected to a dialysate introduction line at a position on a downstream side with respect to a duplex pump. The ultrafiltration line is provided with the ultrafiltration pump. The ultrafiltration pump is capable of performing ultrafiltration by drawing dialysate in the dialysate introduction line through the ultrafiltration line such that the volume of the dialysate to be introduced into a dialyzer becomes smaller than the volume of waste liquid to be drained from the dialyzer.

An oxygenator includes: a housing; a bubble-removing hollow fiber membrane layer removing a bubble; a gas-exchanging hollow fiber membrane layer exchanging a gas with blood; and a discharge port to discharge the bubble removed by the bubble-removing hollow fiber membrane layer to the outside of the housing. The oxygenator further includes a gas permeable portion that is arranged between the discharge port and an end portion of the bubble-removing hollow fiber membrane layer, is formed by a member having gas permeability, and allows passage of the bubble removed by the bubble-removing hollow fiber membrane layer without allowing passage of plasma leaking through the bubble-removing hollow fiber membrane layer. A plasma capture chamber that captures the plasma leaking through the bubble-removing hollow fiber membrane layer is formed between the end portion of the bubble-removing hollow fiber membrane layer and the gas permeable portion.

In a blood purification device containing a blood purifier, a blood circuit, a blood pump, and a dialysate line having a fresh dialysate supply line and a used dialysate discharge line, a pair of plunger pumps are disposed in the dialysate line. The pair of plunger pumps are synchronized so that delivery of a fresh dialysate from one plunger pump and suction of a used dialysate into the other plunger pump simultaneously occur and the stroke of at least one of the pair of plunger pumps is made variable.

A device for extracorporeal blood treatment, in particular a dialysis machine, including an internal fluidic system to which a blood treatment unit, in particular a dialyzer, can be connected, the internal fluidic system comprising at least one balancing chamber on the fresh flow side for balancing fresh treatment fluid flowing to the blood treatment unit and at least one balancing chamber on the used flow side for balancing used treatment fluid flowing off the blood treatment unit, wherein the device has a measuring device for gravimetric detection of treatment fluid in the balancing chamber on the fresh flow side and/or a measuring device for gravimetric detection of treatment fluid in the balancing chamber on the used flow side. A method of balancing treatment fluid in such a device.

The present invention relates to a dialysis machine having a dialyzer and having a first balancing chamber and having a second balancing chamber, wherein the first inflows of the first balancing chamber halves are in fluid communication with a source of fresh dialyzate and the first outflows of the first balancing chamber halves are in fluid communication with a dialyzer inflow, and wherein the second inflows of the second balancing chamber halves are in fluid communication with a dialyzer outflow and the second outflows of the second balancing chamber halves are in fluid communication with a drain, wherein a third balancing chamber is provided that has two balancing chamber halves that are separated from one another by a movable wall, wherein each of the balancing chamber halves has a respective inflow and a respective outflow that are each provided with valves that are configured to close or open the respective inflow or outflow, wherein the two inflows are in fluid communication with a source of fresh dialyzate, and wherein the two outflows are in fluid communication with the dialyzer inflow.

A reciprocation pump has a supply liquid-side sub-pumping chamber arranged adjacent to the supply liquid-side pumping chamber at an external side. A waste liquid-side sub-pumping chamber is arranged adjacent to the waste liquid-side pumping chamber at an external side. A rod extends through the supply liquid-side sub-pumping chamber, the supply liquid-side pumping chamber, the waste liquid-side pumping chamber and the waste liquid-side sub-pumping chamber. The rod is connected to the reciprocation mechanism and the driving source to transmit a driving force of the driving source to the reciprocation mechanism. Sealing members are arranged, respectively, in walls through which the rod extends to partition the supply liquid-side pumping chamber and the supply liquid-side sub-pumping chamber as well as the waste liquid-side pumping chamber and the waste liquid-side sub-pumping chamber.

A peritoneal dialysis system includes a control unit configured to cause (i) a fluid inlet valve and a fluid outlet valve to occlude a fluid inlet line and a fluid outlet line, respectively, while a linear actuator moves a piston to create a positive pressure within a pump housing, the positive pressure measured by a pressure sensor, and (ii) the fluid inlet valve to occlude the fluid inlet line and the fluid outlet valve to open the fluid outlet line, while the linear actuator moves the piston so as to maintain the positive pressure within the pump housing while fluid is pumped out of the fluid pump chamber via the opened fluid outlet line.

A peritoneal dialysis system includes a chamber; a hydraulic pump; an inflatable bladder located within the chamber and in hydraulic fluid communication with the hydraulic pump; and a control unit configured to cause a known amount of hydraulic fluid to be metered to the inflatable bladder and to determine (i) a first amount of air before a discharge stroke of the hydraulic pump via a first ideal gas law calculation, (ii) a second amount of air after the discharge stroke of the hydraulic pump via a second ideal gas law calculation, and (iii) a discharge volume of fresh or used dialysis fluid for the discharge stroke by subtracting a difference between the first amount of air and the second amount of air from the known amount of hydraulic fluid metered to the inflatable bladder for the discharge stroke.