An occlusion assembly for compressing a pair of collapsible tubes comprises an occluding member for each tube. Each occluding member is forced into an occluding position by a spreader positioned within a space between the occluding members that slides along a side of each occluding member causing a tube-contacting portion of each occluding member to compress the collapsible tubes. A main spring may be included that urges the spreader toward the distal ends of the occluding members and into an occluding position. The spreader may be moved against the biasing force of the main spring into a non-occluding position near the proximal ends of the occluding members either manually through a button and linkage assembly coupled to the spreader, or by an automatic actuator coupled to the spreading element.

The present invention relates to a blood treatment cassette having a cassette body, embodied as a hard part, and a film, wherein the film is connected with the hard part and covers the hard part at least partially, wherein the hard part comprises at least one valve seat or valve section or one valve base of a valve, wherein the valve is embodied to take, in addition to a first, open position of the valve in which the valve base and the section of the film positioned above it do not touch each other, a second, closed position of the valve when applying force on the section of the film and wherein the valve base, in its longitudinal extension, comprises or is a non-straight section. The present invention also relates to a blood treatment apparatus connected with a blood treatment cassette.

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (UF) volume over a treatment; a graphical user interface (GUI) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

An optical monitoring system is provided for use with a blood processing system having a yoke that rotates an umbilicus about a rotational axis at a first speed, which causes rotation of an associated centrifuge at a second speed about the rotational axis that is different from the first speed. The system includes a light source configured to illuminate a disposable flow circuit received in the centrifuge and a light detector configured to receive an image of the disposable flow circuit to detect the location of an interface between separated blood compenents within the disposable flow circuit. The monitoring system may be positioned outside of the centrifuge bucket which receives the centrifuge and is configured to be in a fully operational mode for interface detection only when a transparent portion of the centrifuge is visible to the monitoring system.

A blood treatment cassette having a cassette body, designed as a hard part, and a film, wherein the film is connected with the hard part and covers the hard part at least partially, wherein the hard part comprises at least one valve base of a valve and wherein the valve is embodied to take, in addition to a first, open position of the valve in which the valve base and the section of the film that is arranged above it do not touch each other, a second, closed position of the valve when applying force on the section of the film in which the valve base and the section of the film touch each other.

A renal failure therapy machine includes a blood cleaning filter, a sorbent device configured to regenerate used therapy fluid from the blood cleaning filter, a therapy fluid pump configured to pump regenerated therapy fluid from the sorbent device back to the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the therapy fluid pump and the sorbent device, the flow restrictor configured to cause regenerated therapy fluid pumped by the therapy fluid pump from the sorbent device to the blood cleaning filter to be pressurized so that a first amount of the regenerated therapy fluid performs convective clearance and a second amount of the regenerated therapy fluid performs diffusive clearance.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

A blood treatment cassette having a cassette body comprising a hard part and a film that at least partially covers the hard part. The hard part comprises a valve base that cooperates with a section of the film adjacent the valve base to form a valve that is configured to be moved from a first open position in which the valve base and the section of the film do not touch each other to a second position in which the valve base and the section of the film touch each other when a force is applied to the section of the film. The blood treatment cassette comprises a spacer supported by the hard part, and the spacer is configured to apply, in the first position of the valve, force to the section of the film.

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (UF) volume over a treatment; a graphical user interface (GUI) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

A dialysis system includes a fresh dialysis fluid pump, a used dialysis fluid pump, a fresh fluid flow path, a used fluid flow path, and a dialysis fluid cassette carrying a balance chamber, the balance chamber including a first rigid portion, a second rigid portion, and a flexible sheet located between the first and second rigid portions, the flexible sheet dividing the balance chamber into (i) a fresh dialysis fluid compartment connected fluidly to the fresh dialysis fluid pump via the fresh fluid flow path, wherein fresh dialysis fluid contacts the first rigid portion and a first side of the flexible sheet, and (ii) a used dialysis fluid compartment connected fluidly to the used dialysis fluid pump via the used fluid flow path, wherein used dialysis fluid contacts the second rigid portion and a second side of the flexible sheet.