A computer-implemented method for approving a medical device disposable component used in a medical procedure comprising providing an identifiable feature on a medical device disposable component, wherein the identifiable feature comprises one or more photo-identifiable entities having a first emission pattern when in an unexcited state and a second emission pattern when in an excited state. The method also comprises illuminating the identifiable feature with an excitation light source to elicit the second emission pattern, detecting the second emission pattern and comparing the second emission pattern against a set of established reference emission patterns, and determining whether the medical device disposable component is approved based on comparison of the second emission pattern to the set of established reference emission patterns.

During a first stage of a priming procedure, a priming fluid is conveyed into a spinning membrane separator via a filtrate outlet port so as to convey air out of the spinning membrane separator via an inlet port and a retentate outlet port of the spinning membrane separator. During an optional second stage of the priming procedure, the priming fluid is conveyed into the spinning membrane separator via the inlet port so as to convey air out of the spinning membrane separator via the retentate outlet port. A rotor positioned within a housing of the spinning membrane separator may be rotated with respect to the housing during the first and second stages to force air from within the rotor into an annulus defined between the rotor and the housing for more complete priming of the spinning membrane separator.

A system for controlling a fluid procedure comprising a reusable separation apparatus controlled by a microprocessing controller. A sterile circuit is configured to associate with the reusable separation apparatus and provide a first fluid flow path in association with a pressure sensor in communication with the controller and a first pump configured to transmit pulsatile pressure signals to the pressure sensor during operation in association with the first fluid flow path. The reusable apparatus and the controller are configured to receive from the pressure sensor pressure signals comprising the pulsatile pressure signals, perform a frequency analysis of the pressure signals received by the pressure sensor over a time duration, derive a first rotation rate of the first pump or a first fluid flow rate at the first pump from the frequency analysis, and provide a response action based on the first rotation rate or the first fluid flow rate.

A fluid processing device includes a controller, a centrifuge configured to receive and rotate a continuous-flow centrifuge chamber, a pump system, an optical detection assembly, and a pressure sensor. The controller executes a priming procedure in which a priming fluid is conveyed into the centrifuge chamber while the chamber is being rotated by the centrifuge, which moves air out of the chamber via a low-g outlet conduit. Upon detecting priming fluid exiting the centrifuge chamber via the low-g outlet conduit, the chamber is rotated at a higher rate to attempt to move any remaining air out of the chamber via the low-g outlet conduit. The controller then determines, based on signals from the optical detection assembly and pressure sensor, whether there is any air remaining in the centrifuge chamber. If so, the rotational rate is alternately decreased and increased until all the air has been cleared from the centrifuge chamber.

The present invention relates to a blood treatment machine having a control, having a pump actuator for pumping blood through an extracorporeal blood circuit which comprises an arterial line and a venous line, and having a pressure sensor for detecting the pressure in the venous line, wherein the control has a detection function for detecting a venous needle disconnect which compares a value determined on the basis of the pressure in the venous line with a limit value to recognize a venous needle disconnect, wherein the limit value with which the detection function compares the value determined on the basis of the pressure in the venous line can be set variably and/or is set variably by the control.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Intravascular blood pumps and methods of use. The blood pump include a pump portion that includes a collapsible blood conduit defining a blood flow lumen between an inflow and an outflow. The pump portion includes a distal collapsible impeller axially spaced from a proximal collapsible impeller, at least a portion of each of the distal and proximal collapsible impellers disposed between the inflow and the outflow.

Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. During a mononuclear cell collection cycle, blood is removed from a source and separated into a plasma constituent, a mononuclear cell-containing layer, and red blood cells, followed by the collection of a pre-product including at least a portion of the mononuclear cell-containing layer and at least a portion of the separated red blood cells. The mononuclear cell collection cycle may be repeated, followed by the production of a single mononuclear cell product using the collected pre-product(s). The mononuclear cell product is irradiated using a fixed dose of light, such that the mononuclear cell product is produced so as to have a predetermined volume and a predetermined hematocrit, regardless of the number of pre-products used to produce the mononuclear cell product. Following irradiation, at least a portion of the irradiated mononuclear cell product is returned to the source.

Blood in a separation chamber is separated into a red blood cell layer, a plasma constituent, and a mononuclear cell-containing layer. A portion of the plasma constituent exits the chamber via a plasma outlet, while a first portion of the red blood cell layer exits via a red blood cell outlet. A second portion of the red blood cell layer exits the chamber via the red blood cell outlet and is collected. At least a portion of the collected red blood cell layer may then be conveyed to the chamber via the red blood cell outlet to convey at least a portion of the mononuclear cell-containing layer out of the chamber via the plasma outlet for collection. A second portion of the plasma constituent may be conveyed out of the chamber via the plasma outlet to more fully collect the mononuclear cell-containing layer without the use of collected plasma.

This disclosure relates to a medical device including, a hard part, a converter, and a conductive path. The hard part has fluid paths for guiding a medical fluid, in particular blood, through the hard part. The converter is arranged to measure a characteristic of the medical fluid while the fluid is present in one of the fluid paths. At least a first section of the converter or of the conductive path is applied to or superimposed on the hard part by a first additive application method. At least a second section of the converter or of the conductive path is applied to the hard part by a second application method. The first and the second additive application methods differ from each other.