A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

A secondary plasma device (SPD) and methods for its use with apheresis machines or similar extracorporeal blood processing systems and capable of collecting cell-free nucleic acids (cfNA) directly from a subject's circulating plasma, the SPD comprising: i. a sterile capsule having an inlet port and an outlet port and enclosing a filtration/adsorption medium, and configured to receive plasma from the extracorporeal blood processing circuit through the inlet port, such that plasma enters under pressure and flows through the filtration/adsorption medium then exits through the outlet port to a return path of the extracorporeal blood processing circuit leading back to the subject; and ii. the filtration/adsorption medium bearing fixed positive charge that captures cfNA from plasma by anion exchange, and from which cfNA can be subsequently recovered in quantities 10 to 1000-fold greater than the amount of cfNA contained in a 5 ml venipuncture specimen of the subject's blood.

A blood processing filter for removing undesirable components from liquid containing a blood component or blood, comprises: a sheet-shaped filter element; and a container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a filtering surface on a side of the inlet space, a filtering surface on a side of the outlet space, and an end surface along peripheries of the pair of filtering surfaces, and the inlet-side container element and the outlet-side container element are provided with a gripper, and the gripper clamps and compresses an outer edge portion of the pair of filtering surfaces, and is caused to adhere to the end surface with melt resin.

A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

The present disclosure is to provide a method for producing polyurethane (PU) nanofibers with significantly improved hydrophilicity by producing water-soluble polymer/PU blend nanofiber by coaxial-electrospinning water-soluble polymer and hydrophobic PU, and, subsequently, dissolving and removing the water-soluble polymer from the blend nanofiber in water.

Flexible housing filters for filtration of fluids and methods of making such filters are disclosed. The filters may include one or more peripheral seals in the flexible housing.

A failsafe system for a medical fluid procedure, comprising a medical fluid processing apparatus comprising a sealer and a programmable controller driven by software, wherein the programmable controller is programmed to recognize a failure event from input from hardware components of the medical fluid processing apparatus. The system also comprises a disposable fluid circuit configured to associate with the medical fluid processing apparatus and comprising a tubing segment configured to fit within the sealer. The programmable controller is configured to seal the tubing segment by activating the sealer surrounding the tubing segment in response to an occurrence of the failure event.

Devices for the removal of cells or other particles from a biological fluid are disclosed. The devices include a removal medium housed within a chamber of a housing. The devices include inlet and outlet ports carried by the walls. One or both of the ports includes a flow path portion having a chamber-communicating portion that has a cross-section that is larger than the cross-section of an adjacent flow path portion.

A blood processing filter for removing undesirable components from liquid containing a blood component or blood, comprises: a sheet-shaped filter element; and a hard container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a filtering surface on a side of the inlet space, a filtering surface on a side of the outlet space, and an end surface along peripheries of the pair of filtering surfaces, the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses an outer edge portion of the pair of filtering surfaces, and a thickness of the filter element is compressed at the gripper to be 0.05 to 0.5 times the thickness.

The present invention relates to a dialysis machine having a hydraulic system that is intended for providing a dialysis solution or an element of the dialysis solution, wherein the hydraulic system has a degassing pump for degassing the dialysis solution or an element of the dialysis solution, and having a pneumatic system in which a vacuum is present at least at times for operating a component of the dialysis machine, wherein there is a connection line between the suction side of the degassing pump and the pneumatic system for a vacuum generation in the pneumatic system.