An improved wedge is provided for a septum and wedge subassembly in a fluid path of a fluid delivery device such as for use in a catheter insertion mechanism of a patch pump. The wedge has a retaining edge to provide axial force to retain a septum therein to obviate need for additional insertion mechanism components to retain the septum in place as a needle passes therethrough to facilitate insertion of a catheter and then retracts. The retaining edge can be rolled or flanged to extend at least partially over a surface of the septum. The wedge is also configured to provide radial compression on the septum to achieve a sufficient needle and septum interface seal to withstand a filling pressure of the fluid delivery device.

Described herein are systems and methods for performing peritoneal dialysis. According to one aspect, the disclosure provides a sterile interface connection for connecting a water purification system to a disposable source of dialysate concentrates. The sterile interface connection can include a chamber comprising an inlet adapted to be connected to the water purification system on a proximal end and a valve on a distal end. The sterile interface connection can also include spring-loaded needle disposed in the chamber. The spring-loaded needle can move between a retracted configuration in which the spring-loaded needle is fully retracted into the chamber and the valve is closed and sealed, and an extended configuration in which the spring-loaded needle extends through the valve into the disposable source of dialysate concentrates.

Systems and methods for drug delivery with pressure sensitive control are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, a drug delivery device coupled to the reservoir to deliver the drug from the reservoir to a patient, a pressure sensor, an output device, and a controller. The controller may be configured to determine if the drug delivery device has completed delivering a dose of the drug to the patient, and if delivery of the dose of the drug is complete, to measure tissue back pressure using the pressure sensor. Subsequently, the controller may be configured to determine if the tissue back pressure is below a first predetermined value, and if so, control the output device at least once and/or control a mechanism to retract an administration member from the patient.

A drug solution administration device includes: an injection unit configured to inject a drug solution in vivo; a container; a push-out mechanism configured to allow the drug solution stored inside the container to flow into the injection unit; a sealing member attached to the push-out mechanism and pressed against a wall surface of the containing space; a drive mechanism configured to generate a drive force for moving the push-out mechanism back and forth; and a control unit is configured such that, when a predetermined time has passed after the control unit controls the drive mechanism to stop operation of the drive mechanism, the control unit controls the drive mechanism to move the push-out mechanism and to shift a position of the sealing member relative to the wall surface of the containing space.

A system for delivering an agent to a patient, comprises a delivery device. The delivery device is configured to deliver a first agent to the patient, and comprises a reservoir, a transcutaneous delivery assembly, a pumping mechanism, a control module, a power supply, and a housing. The reservoir stores the first agent. The transcutaneous delivery assembly delivers the first agent to the patient transcutaneously. The pumping mechanism receives the first agent from the reservoir and propels the first agent to the transcutaneous delivery assembly. The control module controls at least the pumping mechanism. The power supply provides energy to at least the control module and the pumping mechanism. The housing surrounds at least the pumping mechanism. Methods of delivering an agent to the patient are also described.

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Devices, kits and methods described herein are be used at chronic injection site or in conjunction with an indwelling catheter or cannula. A book-like packaging, applicator and/or tensioning device with an opening and optional indicia to align the catheter or cannula to the opening may be used to apply a dressing to a subject. The packaging, applicator and/or tensioning device may apply and/or maintain a strain in an elastic dressing.

A pump assembly for pumping a medication through a cannula, said pump assembly comprising a housing adapted to be attached to a skin of a patient and containing a reservoir assembly having a variable volume liquid chamber configured to contain the medication upon filling of the reservoir assembly, a variable volume gas chamber configured to contain air before filling of the reservoir assembly and a pressure chamber configured to contain a pressure generating element, the liquid chamber, gas chamber and pressure chamber are fluidly sealed with respect to each other; the liquid chamber is selectably fluidly couplable with the cannula and the gas chamber is fluidly couplable with the atmosphere.

The present disclosure is generally directed to a delivery device housed within an outer cartridge and useful for delivering a fluid to the IO space of a subject at a relatively constant volumetric flow rate over an extended period of time. The delivery device may be fluidly coupled to an existing IO access device or IV line positioned in the IO space of the subject or may be coupled to an IO access device disposed within the outer cartridge.

Embodiments of the present disclosure relate to techniques, processes, devices or systems for pump devices. In one approach, a wearable drug delivery device may include a reservoir configured to store a liquid drug, the reservoir including a housing including an outer wall defining an interior chamber, a sealing member, and a slit through the housing, wherein the sealing member is configured to seal the slit. The wearable drug delivery device may further include a delivery pump device including a drive mechanism coupled to the reservoir for driving the liquid drug out of the reservoir, the drive mechanism including a piston head disposed within the interior chamber of the housing, and a lead screw coupled to a drive nut, wherein the drive nut comprises a blade adjacent the piston head, and wherein the blade is positionable through the slit of the housing.