Abstract of the Disclosure Implantable drug delivery devices and methods of making and using the same are provided. The implantable drug delivery devices permit selective activation and deactivation of drug delivery while subcutaneously implanted in a patient without the use of electronic equipment or power. The devices include a bistable member that has two stable states. In a first stable state, the bistable member does not close off a fluidic pathway between a drug reservoir and a drug release aperture, thereby allowing drug release from the device. In a second stable state, the bistable member closes off or narrows the fluidic pathway, thereby reducing or preventing drug release from the device. A patient or another person can reversibly change the bistable member between the first and second stable states by applying pressure on the patient's skin over the site of implantation and/or manipulating the device through the patient's skin at the site of implantation.

The present disclosure provides a method for flow rate compensation in devices, such as infusion pumps. In various embodiments, a computer-implemented method includes determining a location of a plurality of infusion pumps in a pump stack including the plurality of infusion pumps and a fluid supply connected to each of the plurality of infusion pumps. The computer-implemented method also includes determining a reference infusion pump, in the plurality of infusion pumps, and adjusting the flow rate for each infusion pump in the plurality of infusion pumps based on the distance between the infusion pump and the reference infusion pump.

A method of determining a presence of suction in a patient having an implantable blood pump from down-sampled log files. The method comprising calculating a waveform index for each of a plurality of flow rate data points from the down-sampled log files. The calculated waveform index is compared with a predetermined waveform index threshold. A non-suction trough baseline is calculated from the plurality of flow rate data points. A difference between a measured trough and a calculated non-suction trough baseline is compared with a predetermined threshold. The presence of suction for each of the plurality of flow rate data points is determined if the calculated waveform index is greater than the predetermined waveform index threshold and the difference between the measured trough and a calculated non-suction trough baseline is greater than the predetermined threshold.

A wearable infusion device, which is wearable on the body of a patient, comprises at least one reservoir for holding an infusion liquid, a first pump (11), a second pump (12), a first valve (51), a second valve (52), an orientation detector and a controller. The controller is configured for controlling of driving a first plunger (31) of the first pump and a second plunger (32) of the second pump, and for controlling of switching valve positions of the first valve and the second valve. The controller is further configured for determining a tilt angle alert condition in which a tilt angle detected by the orientation detector exceeds a predetermined threshold value. The wearable infusion device is able to automatically respond to relatively heavy movements and shocks in manners to the benefit of the infusion therapy that the patient is undergoing.

An at least partly implantable system for injecting a substance into a patient's body, in particular a penis erection stimulation system, comprises one or more long, flexibly bendable infusion needles, the tip ends of which are disposed within and implanted along with at least one first housing, in particular adjacent the patient's left and right corpora cavernosa. The respective other end or ends of the infusion needles are disposed and implanted along with at least one second housing remote from the first housing. A reservoir and a pump are also implanted inside the patient's body to supply the infusion needle with infusion liquid. A drive unit also adapted for implantation inside the patient's body is arranged for advancing and retracting the infusion needle such that its tip end penetrates the at least one first housing's outer wall in at least one penetration area, more specifically at least in two different penetration areas either simultaneously or in immediate time succession, thereby injecting the substance into the patient's body.

The device presented is designed to cause, in a mode of operation referred to as normal mode, a fluid to flow along this fluid path successively through the first cavity, the filter, the second cavity then the flow restrictor. The device is also designed to cause, in a mode of operation referred to as purge mode, a fluid to flow along this same fluid path through the filter but in the opposite direction to the normal flow of the fluid (in the normal mode of operation). Thanks to the purge mode, the fluid will detach impurities that have become trapped on the filter in order to clean same.

An at least partly implantable system for injecting a substance into the body of a patient is disclosed. The system comprises at least one infusion needle disposed at least partly within at least one housing with a tip end of the infusion needle arranged for penetrating an outer wall of the housing. The system further comprises at least one drive unit adapted to be implanted inside the body and a for advancing and retracting the tip end of the infusion needle so that the infusion needle penetrates, upon advancement, the outer wall to allow for injection of the substance.

The present invention relates to an at least partly implantable system for injecting a substance into a patient's body. The system comprises at least one implantable infusion needle arranged in at least one first housing, the at least one implantable infusion needle having a tip end for injecting a substance into a penetration area of a patient, and at least one drive unit coupled to the at least one implantable infusion needle and arranged for moving the tip end of the at least one infusion needle for varying the penetration site, wherein the at least one drive unit is a drive unit arranged for moving the tip end of the at least one infusion needle using hydraulic force. The system is adapted to use infusion liquid to be injected into the patient's body as hydraulic fluid.

Infusion devices and methods are provided for a drug delivery system and can include an infusion needle (1) having a tip end (2) and a drive unit (D) coupled to the infusion needle and arranged for advancing the tip end of the infusion needle to penetrate any fibrosis when the infusion device is implanted in a patient's body. The infusion needle and drive unit are designed for implantation in a patient's body. Other components of the drug delivery system may be part of the implantable infusion device or, alternatively, be for extracorporal use cooperating with the implanted infusion device. Preferably, the infusion needle can be advanced and retracted with each infusion cycle. Furthermore, upon each advancement and/or retraction, the needle may be moved laterally so as to vary the injection site. Needle (1) and drive unit (D) are preferably disposed within a body (15), with the infusion needle being arranged for penetrating a self-sealing penetration membrane (18).

An at least partly implantable system for injecting a substance into a patient's body, in particular a penis erection stimulation system, comprises one or more long, flexibly bendable infusion needles, the tip ends of which are disposed within and implanted along with at least one first housing, in particular adjacent the patient's left and right corpora cavernosa. The respective other end or ends of the infusion needles are disposed and implanted along with at least one second housing remote from the first housing. A reservoir and a pump are also implanted inside the patient's body to supply the infusion needle with infusion liquid. A drive unit also adapted for implantation inside the patient's body is arranged for advancing and retracting the infusion needle such that its tip end penetrates the at least one first housing's outer wall in at least one penetration area, more specifically at least in two different penetration areas either simultaneously or in immediate time succession, thereby injecting the substance into the patient's body.