Apparatus is described for administering a substance to a subject. A vial contains the substance and a stopper is disposed within the vial and is slidably coupled to the vial. A first threaded element is (a) rotatable with respect to the vial and (b) substantially immobile proximally with respect to the vial during rotation of the first threaded element. A second threaded element is threadedly coupled to the first threaded element. At least a distal end of the second threaded element is substantially non-rotatable with respect to the vial, and the distal end of the second threaded element defines a coupling portion that couples the second threaded element to the stopper. The first threaded element, by rotating, linearly advances the stopper and at least the distal end of the second threaded element toward a distal end of the vial. Other embodiments are also described.

The present disclosure relates to a medicament delivery device. The medicament delivery device includes a needle for delivering a medicament and an insertion mechanism configured to urge the needle in a first direction parallel to a longitudinal axis of the needle. The insertion mechanism includes a driving mechanism and a cam. The driving mechanism is configured to exert a force in a second direction perpendicular to the first direction. The cam is coupled to the needle and is configured to receive a force from the driving mechanism and move in the first direction in response to the received force.

An internal mechanism configured to pump a fluid in an ophthalmic device is provided. The internal mechanism includes an inlet port, a drive member coupled to the actuator and a plunger coupled to the drive member. The drive member provides a force that moves the plunger in a first direction when the actuator moves from an un-pressed position to a pressed position, the movement of the plunger in the first direction causing the fluid to move from the inlet port and through a cannula and causing a portion of the fluid to exit one or more orifices of the cannula. An ophthalmic device having an internal mechanism is also provided.

An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula. The internal mechanism includes a follower fixedly coupled to the sleeve and moveable between distal and proximal positions, and a release member movable between an activated position and a release position. The release member is coupled to the actuator and configured to release a force that urges the follower from the distal position to the proximal position when the release member moves from the activated position to the release position.

A rotary pump for a fluid metering system is provided. The rotary pump reciprocates, and is reversed by a signal from a limit switch that is deflected by an actuator arm on a rotating sleeve of the pump system.

A coupling mechanism for a medication delivery device includes a first part axially fixed relative to a housing and rotatable around a longitudinal axis of the first part, the first part having a gearing engagement to a second part arranged along the longitudinal axis, the gearing engagement having a first frictional resistance. The second part axially moveable along the longitudinal axis, and directly or indirectly in a friction fit engagement with the housing, which has a second frictional resistance. The first frictional resistance being below the second frictional resistance such that a rotation of the first part in a first direction axially longitudinally moves the second part away from the first part and a rotation in a second direction, opposite to the first rotation direction, reduces the axial distance between the first and second part and/or axially moves the second part into coupling abutment with the first part.

A unilateral driving mechanism for a portable infusion system is provided. The unilateral driving mechanism comprises an actuator (1), a swinging part (2), gears (4), blockers (5), a compression spring (6), a rod (7), a reservoir (8), a plunger (9) and a control circuit. One end of the rod (7) is connected with the gears (4), the other end of the rod (7) is connected with the plunger (9), and one lower limb of the swinging part (2) is connected with the spring (6). The unilateral driving mechanism for a portable infusion system has advantages of compact structure, small volume, low power consumption, low cost, high precision and convenience in use.

Embodiments of the invention include a medicament device configured to provide stepwise instructions for using the device to a user in a particular sequence is provided. The device includes a reusable housing configured to receive a container, the reusable housing including a control interface, the control interface including at least one responsive member reactive to a user input, an actuation member configured to interact with the container, a signal output component associated with the reusable housing; and circuitry associated with the reusable housing configured to control a provision of the stepwise instructions to the user in the particular sequence.

A transdermal drug delivery device includes a reservoir, a transdermal membrane, a piston, a control rod, a spring, and a rotational cam. The reservoir is configured to hold a formulation. The transdermal membrane is configured to allow the formulation from the reservoir to pass therethrough. The piston is configured to move into the reservoir. The control rod is attached to the piston and includes a plurality of teeth thereon. The spring is configured to apply force to the control rod in the direction of the reservoir. The rotational cam has a first camming surface and a second camming surface that are configured to engage with the plurality of teeth. The rotational cam, when rotated, is configured to disengage the first camming surface from a first tooth of the plurality of teeth, thereby allowing the spring to advance the piston into the reservoir to expel the formulation onto the transdermal membrane.

A method and apparatus are disclosed for delivery of a drug to a recipient. In some embodiments, the delivery apparatus may unseal a drug containing reservoir. In some embodiments, the delivery rate may be controlled and/or adjustable. Optionally the apparatus may be disposable. Optionally, the apparatus may have a low profile and/or be wearable and/or attachable to the recipient. Optionally, discharge of the drug and/or unsealing of the reservoir may be driven by a plunger moving parallel to the base of the apparatus. Optionally, the apparatus may release a hypodermic needle into the recipient. Optionally, release of the hypodermic needle may be in a direction non-parallel and/or orthogonal to the direction of movement of the plunger. Optionally, prior to release, the hypodermic needle may be preserved in an aseptic state by a needle opening septum sealing a needle opening. Optionally, upon release, the hypodermic needle may pierce the needle opening septum.