Method for detecting failure including possible under or over delivery of a micropump having at least an inlet valve, a pumping chamber with an inner pressure sensor and an outlet valve, said method comprising the determination of the pump tightness via the measurement of the pressure by said inner pressure sensor in said pumping chamber at least at certain intervals when the pump is inactive and the comparison with a value of reference.

An embodiment of a peritoneal dialysis system includes a peritoneal dialysis hardware unit having a housing with a first opening, a door coupled to the housing and having a second opening, and a solid pump piston having a solid piston shaft attached to or integrally formed with a solid piston head. The system also includes a stepper motor operable to cause the solid pump piston to translate; a disposable pumping unit having a first and a second opposing surface, and a fluid pump receptacle extending from the first and second surface to fit within the second opening. The hardware unit and pumping unit are structured and arranged to allow the pumping unit to be placed into the hardware unit such that the fluid pump receptacle is aligned with the first opening, the second opening, and the solid piston head when the door is closed against the housing.

The disclosure provides an electrochemical pump which comprises a substrate and at least one planar electrode and a micro-delivery device comprising the same. The substrate has an upper surface. The planar electrode is disposed on the upper surface and comprises at least one sharp corner.

A liquid supplying device for a human insulin injection includes a substrate, a liquid storage chamber, a flow-guiding-and-actuating unit, a sensor and a driving chip. The flow-guiding-and-actuating unit includes a liquid guiding channel having a liquid guiding outlet in fluid communication with a liquid storage outlet of the liquid storage chamber. The sensor contacts with the human skin to measure a blood glucose level contained in sweat. The driving chip is configured to control the actuation of the flow-guiding-and-actuating unit, control open/closed states of the switching valves and receive the measured data from the sensor for determination. By driving the flow-guiding-and-actuating unit, a pressure gradient is generated, and an insulin liquid stored in the liquid storage chamber is transported to the liquid guiding outlet through the liquid guiding channel, flowing into a microneedle patch, and injected into a subcutaneous tissue through a plurality of hollow microneedles.

A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. The distal end of the rolling diaphragm has a nozzle and a sidewall extending between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Fluid delivery and measurement systems and methods are disclosed.

An orientation independent delivery device including a replaceable cartridge that may be installed on a foundation. A cartridge includes a gas chamber, a delivery chamber, a gas cell, and a delivery aperture. The gas chamber includes a gas-side rigid portion and a gas-side flexible barrier. The gas-side flexible barrier is sealed to the gas-side rigid portion. The delivery chamber includes a delivery-side rigid portion and a delivery-side flexible barrier. The delivery-side flexible barrier is sealed to the delivery-side rigid portion and is oriented adjacent to the gas-side flexible barrier. The gas cell is coupled to the gas-side rigid portion of the gas chamber. The gas cell increases a gas pressure within the gas chamber to expand the gas-side flexible barrier. Expansion of the gas-side flexible barrier applies a compressive force to the delivery-side flexible barrier allowing a delivery material to escape from the delivery chamber.

A medicament delivery device for delivering a dose of medicament into an injection site comprises an expandable reservoir (130) for receiving the medicament, a holder (102) for receiving the reservoir (130), attachment means (104, 110) for securing the holder (102) to the injection site, a cannula (174) moveable from a stowed position in which the cannula (174) does not project from the device (100) to a deployed position in which the cannula (174) provides fluid connection between the reservoir (130) and the injection site, and an elastic element (106). In use, the elastic element (106) is held under strain by the medicament in the reservoir (130) and delivery of the medicament through the cannula (174) is driven by relaxation of the elastic element (106) when the cannula (174) is in the deployed position. The device is preferably in the form of an arm band or a patch.

The present invention discloses a liquid medicine injection device that is attached to a patient's body to inject liquid medicine such as insulin at an appropriate time.

A liquid medicine injection device according to the present invention includes: a case; a liquid medicine tank that is disposed in the case and where liquid medicine is received; an electro-osmosis pump that is connected with the liquid medicine tank and moves the liquid medicine; a needle assembly that receives the liquid medicine by being connected to the electro-osmosis pump and injects the received liquid medicine into a human body; and an adhesive member combined to the case and attached to the human body.

Fluid delivery and measurement systems and methods are disclosed.