A device for injecting contrast agent includes a supply line with a pressure regulator and leading to a soft injection bag in fluid communication with the supply line and with a catheter. The device also includes a pair of clamping plates acting on the injection bag and arranged on opposite sides of the injection bag. The clamping plates can be moves away from and close to each other. The device also includes a pair of inflatable compression bags. The compression bags are inflated with compressed air and act on corresponding clamping to plates to force the clamping plates to move close to each other and thus compress the injection bag. According to a method of the invention, the injection bag is filled from the source through the pressure regulator and a constant volume load container, and a contrast agent is supplied from the injection bag by gradually compressing the injection bag.

A bolus delivery device is provided that comprises a housing and a reservoir defined by an activation dome and a reservoir seat and disposed within the housing for receipt of a volume of a fluid. The bolus delivery device further comprises a bladder disposed in the housing that is in fluid communication with the reservoir for receipt of the fluid from the reservoir; an actuator; an inlet conduit in fluid communication with the reservoir for providing the fluid to the reservoir; and an outlet conduit in fluid communication with the bladder for providing the fluid to a patient. The actuator is in operative communication with the reservoir to initiate a flow of the fluid from the reservoir to the bladder. The bladder expands as the bladder receives the fluid and contracts as the bladder dispenses the fluid. An infusion assembly including a bolus delivery device also is provided.

A bolus delivery device is provided that comprises a housing and a reservoir defined by an activation dome and a reservoir seat and disposed within the housing for receipt of a volume of a fluid. The bolus delivery device further comprises a bladder disposed in the housing that is in fluid communication with the reservoir for receipt of the fluid from the reservoir; an actuator; an inlet conduit in fluid communication with the reservoir for providing the fluid to the reservoir; and an outlet conduit in fluid communication with the bladder for providing the fluid to a patient. The actuator is in operative communication with the reservoir to initiate a flow of the fluid from the reservoir to the bladder. The bladder expands as the bladder receives the fluid and contracts as the bladder dispenses the fluid. An infusion assembly including a bolus delivery device also is provided.

Presented herein are methods, systems, and apparatus for administering a monoclonal and/or polyclonal antibody treatment via a rapid infusion device, e.g., for the treatment of a disease, e.g., a disease caused by a pathogen, e.g., for the treatment of COVID-19, caused by the virus SARS-CoV-2, or for the treatment of other conditions/diseases, such as neurological diseases, organ and/or tissue transplants, or certain forms of cancer, that require infusions of monoclonal and/or polyclonal antibodies.

Presented herein are methods, systems, and apparatus for administering a monoclonal and/or polyclonal antibody treatment via a rapid infusion device, e.g., for the treatment of a disease, e.g., a disease caused by a pathogen, e.g., for the treatment of COVID-19, caused by the virus SARS-CoV-2, or for the treatment of other conditions/diseases, such as neurological diseases, organ and/or tissue transplants, or certain forms of cancer, that require infusions of monoclonal and/or polyclonal antibodies.

Mandrels and elastomeric pumps for infusion assemblies are provided. For example, a mandrel may comprise a body extending over a length from a first end to an opposing second end; an outer diameter; a bore extending within the body; an inlet port defined near the first end; and a fill port defined between the first and second ends. The inlet and fill ports are in fluid communication with the bore. The outer diameter of the mandrel at a midpoint of the length is different than the outer diameter at each of the first end and the second end. In some embodiments, the outer diameter of the mandrel gradually transitions from a first outer diameter at the first end to a second outer diameter at the second end. An elastomeric pump may include an exemplary mandrel and an inflatable elastomeric bladder disposed on the mandrel.

Mandrels and elastomeric pumps for infusion assemblies are provided. For example, a mandrel may comprise a body extending over a length from a first end to an opposing second end; an outer diameter; a bore extending within the body; an inlet port defined near the first end; and a fill port defined between the first and second ends. The inlet and fill ports are in fluid communication with the bore. The outer diameter of the mandrel at a midpoint of the length is different than the outer diameter at each of the first end and the second end. In some embodiments, the outer diameter of the mandrel gradually transitions from a first outer diameter at the first end to a second outer diameter at the second end. An elastomeric pump may include an exemplary mandrel and an inflatable elastomeric bladder disposed on the mandrel.

An infusion pump includes a core member and a bladder member which are substantially spheroidal at one end and cylindrical at the other end. The core member is inserted inside the bladder member and a ring member engages the cylindrical ends of the core and bladder member to sealingly secure the bladder to the core. A tubular hose is included and is coupled with an infusion port of the core member. When fluid is injected into the pump, it causes the bladder member to inflate substantially symmetrically and spherically around an axial axis of the core member. Upon deflating the bladder member, the fluid is ejected out of the pump at a constant flow rate.

An infusion pump includes: infusion-tube pressing parts configured to press a flexible infusion tube; an infusion-tube receiving surface configured to serve as a receiving surface when the infusion-tube pressing parts press the infusion tube; and a restoration device provided between the infusion-tube pressing parts, the restoration device being configured to move together with the infusion-tube pressing parts along the infusion-tube receiving surface and to press two sides of the infusion tube pressed by the infusion-tube pressing parts, wherein the infusion-tube pressing parts is configured to move sequentially in a longitudinal direction of the infusion tube along the infusion-tube receiving surface to deliver a liquid in the infusion tube in one direction while pressing the infusion tube by sandwiching the infusion tube with the infusion-tube receiving surface.

An infusion pump includes: infusion-tube pressing parts configured to press a flexible infusion tube; an infusion-tube receiving surface configured to serve as a receiving surface when the infusion-tube pressing parts press the infusion tube; and a restoration device provided between the infusion-tube pressing parts, the restoration device being configured to move together with the infusion-tube pressing parts along the infusion-tube receiving surface and to press two sides of the infusion tube pressed by the infusion-tube pressing parts, wherein the infusion-tube pressing parts is configured to move sequentially in a longitudinal direction of the infusion tube along the infusion-tube receiving surface to deliver a liquid in the infusion tube in one direction while pressing the infusion tube by sandwiching the infusion tube with the infusion-tube receiving surface.