An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

An injection device (10) comprising a housing (12), a needle hub (38) slidable within the housing (12), a needle (40) having a distal end piercing tip (42) and a proximal end piercing tip (44), the needle hub being moveable from a first position wherein the distal end piercing tip (42) is within the housing to a second position wherein the distal end piercing tip (42) extends outwardly of the housing (12), a spring (23) biassing the needle hub (38) towards the first position, and a cartridge receiving member (48) mounted within the housing (12), and a plunger rod assembly (66) for exerting pressure on the cartridge receiving member (48) to move the cartridge (26) and the needle hub (38) from the first position to the second position, the plunger rod assembly (66) and the cartridge receiving member (48) being arranged such that when the cartridge rod assembly is pushed, a rotational movement is imparted to the cartridge receiving member (48) to thereby prevent access to the cartridge after injection.

A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

The present disclosure relates to a medicament container, configured as a flexible bag. The flexible bag includes a proximal end and a distal end having an outlet port. The flexible bag is configured to increase in length between the proximal end and the distal end when being collapsed.

The mixing system includes an adaptor, an integrated injection device removably attached to the adaptor comprising a switching element, a first reservoir containing a fluidic first material, and a trigger. The adaptor includes a first attachment location configured to attach a vial. The vial contains a second material within a second reservoir, wherein the second material contains a medicament formulation. The adaptor also includes a first connection element, a flow channel providing fluid communication of the switching element and the first connection element, a sensing arrangement for detecting a pre-defined position of the vial at the first attachment location, and an interlock element which is configured to allow operation of the trigger in order to establish a fluid communication between the first connection element and the first reservoir only if the sensing arrangement detects the pre-defined position of the vial at the first attachment location.

An administration device including a needle; a cartridge which is capable of storing a liquid medicine to be administered into a living body by the needle; a case which has an open or openable first end to be pressed against the skin, and in which the needle and the cartridge are stored in such a manner as to be movable toward the first end side, the needle being capable of moving to the outside of the first end in response to the movement of the needle toward the first end ide; and a pressing force control member which intervenes so as to generate a reactive force between the cartridge and the case and which controls a pressing force exerted on the skin by the case while the needle moves toward the first end side. In the process of piercing by the needle, a reactive force is continuously generated by the pressing force control member and the pressing force exerted on the skin by the case is controlled at a substantially constant level, whereby the piercing depth by the needle is kept substantially constant at the time of completion of the piercing by the needle; and in the process of discharging the liquid medicine stored in the cartridge through the needle for administration, the reactive force by the pressing force control member is generated continuously, whereby the piercing depth by the needle is kept substantially constant.

The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

An injector device comprising an elongate housing having a proximal end and a distal end, and configured to receive a container of medicament, a needle sleeve mounted within the housing and moveable between an extended position in which the needle sleeve at least partially extends from the distal end of the housing, and a retracted position in which the needle sleeve is received further within the housing than in the extended position, a piston rod moveable longitudinally within the housing, a piston spring configured to bias the piston rod towards a distal end of the housing to engage a container of medicament when received within the housing, and a release mechanism configured to control actuation of the piston rod. The release mechanism comprises a locking arm moveable between a locked position in which the locking arm is in cooperating engagement with the piston rod and prevents movement of the piston rod, and a release position in which the locking arm is out of engagement with the piston rod so that the piston rod is free to move longitudinally within the housing. The needle sleeve is configured such that movement of the needle sleeve from the extended position to the retracted position causes the locking arm to move from the locked position to the release position.

The present invention relates to a medicament delivery device comprising, a housing (10, 114) having a proximal and a distal end, a delivery member connected to the housing; a medicament container (84) operably arranged within the housing; a drive mechanism (102, 108) capable of acting on the medicament container (84) for priming and for expelling a dose of medicament. The invention is characterised in that the device further comprises - an activator mechanism configured to interact with the drive mechanism, such that a first interaction between the activator mechanism and the drive mechanism causes the container to move towards the delivery member wherein the container is primed and such that a subsequent second interaction between the activator mechanism and the drive mechanism causes a dose of medicament to be expelled through the delivery member. (FIG. 3)