A medicament delivery device is presented having a housing, a container assembly, a needle assembly and a driver assembly. The container assembly includes a medicament container having an interior containing a medicament. The needle assembly is connected to the container assembly and has a needle and an outer cap, wherein the outer cap is configured to be manually manipulated to move the needle toward the medicament container in order for a distal end of the needle to pierce a first seal and enter an interior of the medicament container. The driver assembly is disposed at a distal end of the medicament container and configured to be released and move the container assembly and the needle assembly toward the proximal end of the housing to an insertion position where a proximal end of the needle exits the housing.

A medicament delivery device is presented having a housing with a proximal end and a distal end, a multi-chamber container arranged in the housing, a power assembly having accumulated energy arranged in the housing and configured to act on the multi-chamber container for obtaining and delivering a blended compound inside the multi-chamber container and a manually operable assembly extending from the distal end of the housing and being connected with the power assembly, wherein upon a manual movement of the manually operable assembly the power assembly is forced to move towards the proximal end to pressurize the multi-chamber container and wherein the medicament delivery device further comprises a needle shield sleeve slidably arranged in the housing, the needle shield sleeve being configured to interact with the power assembly to release the accumulated energy after the power assembly has been moved towards the proximal end.

A medicament injection device includes a main body configured to receive a medicament cartridge sealed by a first penetrable barrier, a cap assembly including a button cap and a carrier unit, the button cap being rotatable with respect to the carrier unit and wherein the button cap is prevented from being displaced axially in a proximal direction unless the button is rotated into alignment with respect to the carrier unit, a needle carrier releasably coupled to the carrier unit, the needle carrier carrying a needle having a proximal end and a distal end, the needle carrier being releasably coupled to the push button. Subsequent to rotational alignment of the button cap with respect to the carrier unit, the button cap is axially displaceable in the proximal direction. Axial displacement of the button cap in the proximal direction causes the needle carrier to be displaced axially in the proximal direction.

An attachable needle assembly (2) for use on a medication delivery pen (4), the needle assembly (2) comprising a housing (16) that engage the medication delivery pen (4), the housing (16) enclosing a plurality of needles (34) that pierce a reservoir septum (6) of the medication delivery pen (4), a plurality of needle posts (24) each securing one of the plurality of needles (34), and a needle assembly septum (60) enclosing the plurality of needles (34). The needle assembly (2) further including a plurality of integrated peel tabs (70) each detachably connected to one of the plurality of needle posts (24), wherein in a first position of the needle assembly (2), the plurality of needles (34) is disposed in the needle assembly septum (60), and in a second position of the needle assembly (2), one of the plurality of integrated peel tabs (70) is drawn out of the housing (16) to cause a selected needle (40) of the plurality of needles (34) to pierce the needle assembly septum (60) and be exposed for medication delivery.

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

Systems and methods for mixing and/or reconstituting drugs are presented. A system may include an injection device, a vial, a needle, and a base station. The device has a chamber containing a first material. The vial has a chamber containing a second material. A drive unit of the base station moves the vial and/or the housing of the device relative to each other into an activated position. In the activated position, the needle is fluidly connected with the vial's chamber, and the drive unit is connected to a driver that moves the plunger in the axial direction of the device such that during fluid connection of the needle with the vial's chamber the first material is expelled from the device's chamber into the vial's chamber or the second material is expelled from the vial's chamber into the device's chamber.

The disclosure relates to a drug delivery device, comprising: an outer needle sleeve; a cartridge containing a dosage of a medicament and sealed with a sealing element that is arranged across an open distal end of the cartridge; a cartridge carrier adapted to hold the cartridge; a needle hub adapted to hold a double ended hollow needle; an inner needle sleeve arranged between the needle hub and the cartridge carrier; a removable cap coupled to the inner needle sleeve and adapted to cover and seal the needle; and a first locking mechanism adapted to lock the inner needle sleeve against axial movement in the proximal direction with respect to the cartridge carrier in an initial state, wherein in the initial state, the needle is spaced from the cartridge in the distal direction, and wherein the first locking mechanism is releasable by a rotational movement of the cap with respect to the outer needle sleeve.

The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

An injector device comprising an elongate housing having a proximal end and a distal end, and configured to receive a container of medicament, a needle sleeve mounted within the housing and moveable between an extended position in which the needle sleeve at least partially extends from the distal end of the housing, and a retracted position in which the needle sleeve is received further within the housing than in the extended position, a piston rod moveable longitudinally within the housing, a piston spring configured to bias the piston rod towards a distal end of the housing to engage a container of medicament when received within the housing, and a release mechanism configured to control actuation of the piston rod. The release mechanism comprises a locking arm moveable between a locked position in which the locking arm is in cooperating engagement with the piston rod and prevents movement of the piston rod, and a release position in which the locking arm is out of engagement with the piston rod so that the piston rod is free to move longitudinally within the housing. The needle sleeve is configured such that movement of the needle sleeve from the extended position to the retracted position causes the locking arm to move from the locked position to the release position.