A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.

The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

A medicament injection device comprising a main body arranged to receive a medicament cartridge; a needle carrier carrying a needle, wherein the needle carrier is axially movable with respect to the main body; and a rotatable cap at a distal end of the device, wherein the cap is removably coupled to the needle carrier, a releasable arrangement between the main body and the cap comprising a guide element and a slotted link, wherein the slotted link is arranged to cause the guide element to follow a predefined path at least partly in an axial direction during rotational movement of the cap, thereby causing the needle carrier to move axially towards a proximal end of the device as the cap is rotated up to a predefined point, wherein the main body comprises a medicament cartridge holder comprising the guide element depending therefrom for engagement with the cap.

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

An electronic system (200) connectable to a medication delivery pen (4) and a needle assembly (2, 102), the electronic system (200) exchanging data regarding a medicament traveling from the medication delivery pen (4) to the needle assembly (2, 102), the electronic system (200) comprising a hub (202) having a spike (204) that is configured to engage the medication delivery pen (4) and pierce a reservoir septum of the medication delivery pen (4), a flow sensor (220) that is in fluid communication with the hub (202) to measure flow data of the medicament, a circuit board (250) electrically contacting the flow sensor (220) to process and transmit the flow data, the circuit board (250) including a fluid path hole (254) to route a flow of medicament, and a septum body (270, 284) that is configured to provide fluid communication between the flow sensor (220) and one of a plurality of needles (40, 124) of the needle assembly (2, 102) to administer the medicament to a patient.

A connector retains a medicine reservoir in a housing. The connector snaps onto the reservoir, the connector and reservoir are inserted into an aperture in the housing, and the connector snaps into the aperture in the housing. The connector may have a tubing and needle fixed in it to insert into the reservoir. The connector does not require a particular orientation when snapped into the housing and some embodiments may rotate freely. When snapped into the housing, the connector provides an auditory cue. For removal of the connector and reservoir, the exposed portion of the connector is compressed from the side. The configuration of the connector solves several problems associated with threaded connectors or other similar connectors.

A mix and triggering assembly for a medicament delivery device, comprising: a housing structure having a proximal end and a distal end, a delivery member cover, a rotator sleeve, and a triggering member configured to be rotatably locked with the rotator sleeve and the delivery member cover, the triggering member being configured to move axially relative to the rotator sleeve, wherein the delivery member cover, the rotator sleeve and the triggering member are configured to be received by the housing structure, the delivery member cover being configured to extend from the proximal end of the housing structure, wherein the delivery member cover, the rotator sleeve and the triggering member are rotatably arranged relative to the housing structure, wherein the housing structure has a thread structure and the rotator sleeve and the triggering member are configured to be in a threaded connection with the thread structure in a ready to mix position of the triggering member, preventing irrotational axial movement of the triggering member relative to the housing structure towards the distal end of the housing structure, wherein rotation of the delivery member cover relative to the housing structure causes the rotator sleeve and the triggering member to be screwed from the ready to mix position towards the distal end of the housing structure until the triggering member reaches a dose setting position, in which the triggering member is configured to be released from engagement with the thread structure, enabling irrotational axial movement of the triggering member further towards the distal end of the housing structure.