A mixing vial having a hollow interior chamber with a tubular portion having distal and proximal open ends and a stopper positioned in sealing relationship in the tubular portion, the stopper having a hollow interior chamber with an open end and a dislodgeable plug positioned in and sealing the open end.

One aspect relates to a device for producing a bone cement paste from a monomer liquid and a cement powder and for delivering the bone cement paste, the device having a cartridge with a cylindrical interior, the interior of the cartridge being closed at the front side apart from a delivery opening for discharging the bone cement paste from the interior. A delivery plunger is arranged in the interior of the cartridge and mounted so as to be pushable in the direction of the delivery opening. The cement powder is arranged in the interior of the cartridge between the delivery opening and the delivery plunger. A closure closes the delivery opening and is mounted so as to be movable relative to the delivery opening. A line element is arranged at the front side of the delivery opening and includes a closure receptacle for receiving at least part of the closure. The closure is pushable into the closure receptacle by pressure on the bone cement paste such that the delivery opening is opened, when the closure has been pushed into the closure receptacle, the line element provides a free line cross-section through which the bone cement paste is pushable out through the delivery opening and out of the device.

An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.

A mixing vial having a hollow interior chamber with a tubular portion having distal and proximal open ends and a stopper positioned in sealing relationship in the tubular portion, the stopper having a hollow interior chamber with an open end and a dislodgeable plug positioned in and sealing the open end.

A closure piece for a powder syringe is proposed, having a main body, a sealing element, which is disposed on the main body such that it rests in a sealing manner against a distal opening of a powder syringe, when the closure piece is disposed in the closing position thereof on the powder syringe, and a channel, which passes through the main body and the sealing element and has a proximal and a distal end. The closure piece is characterized by a retaining element, which is configured and/or can be disposed such that, prior to an activation of the powder syringe, any powder from a chamber of the powder syringe is at least substantially, preferably completely, prevented from penetrating the channel, when the closure piece is disposed in the closing position thereof on the powder syringe.

A closure piece for a powder syringe has a main body and a sealing element. The sealing element is disposed on the main body such that it rests in a sealing manner against a distal opening of a powder syringe when the closure piece is disposed in the closing position thereof on the powder syringe. A channel passes through the main body and the sealing element and has a proximal and a distal end. The closure piece includes a retaining element configured and/or disposed such that, prior to an activation of the powder syringe, any powder from a chamber of the powder syringe is at least substantially prevented from penetrating the channel when the closure piece is disposed in the closing position thereof on the powder syringe.

A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber. According to this combination container/syringe, it is possible to effectively eliminate air bubbles in a medicinal solution via a medicinal solution flow-through space that is formed over the circumferential direction between the inner peripheral surface of the bypass chamber and the outer peripheral surface of the front stopper.

A stopper device (1) seals off a medicament container (45) with a stopper element (3), wherein the stopper device is designed to seal the medicament container (45) in an axial direction of a center axis (M) of the medicament container (45), wherein the stopper device (1) is at least partially insertable into the medicament container (45), and the stopper element (3), in the intended installation position in the medicament container (45), is displaceable along the center axis (M) of the medicament container (45). The stopper device (1) has a retention region (23) with at least one retention means (5), wherein a closure element (7), in a first functional state of the stopper device (1), is retained by the retention means (5) in a fixed position relative to the stopper element (3), in particular retained releasably in a retention position on the stopper element (3), in such a way that a cavity (29) is formed between the closure element (7) and the stopper element (3).

The present disclosure relates to a stopper configured to be positioned inside a barrel of an injection device for injecting at least one composition, said stopper including: a gasket including a proximal end, a distal end, a lateral wall, and a through hole extending from the proximal end to the distal end, an insert inserted in the through hole, wherein the stopper is adapted to deform between: a closed configuration wherein the gasket cooperates with the insert to hermetically close the through hole, for preventing flow of the composition between the proximal end and the distal end of the gasket, and an open configuration wherein the gasket cooperates with the insert to open a fluidic pathway in the through hole between the proximal end and the distal end of the gasket for allowing flow of the composition.

The present disclosure relates to a stopper configured to be positioned inside a barrel of an injection device for injecting at least one composition, said stopper including: a gasket including a proximal end, a distal end, a lateral wall, and a through hole extending from the proximal end to the distal end, an insert inserted in the through hole, wherein the stopper is adapted to deform between: a closed configuration wherein the gasket cooperates with the insert to hermetically close the through hole, for preventing flow of the composition between the proximal end and the distal end of the gasket, and an open configuration wherein the gasket cooperates with the insert to open a fluidic pathway in the through hole between the proximal end and the distal end of the gasket for allowing flow of the composition.