A delivery system for delivering a drug depot to a site within a patient, the system comprising: a cannula; a delivery stylet configured and dimensioned to be receivable by and slidable forwardly and backwardly within the cannula including to a position wherein a distal portion of the stylet protrudes beyond the distal end of the cannula; a drug depot retainable by the stylet at the distal end of the stylet, the drug depot being visualizable by a diagnostic imaging beam or modality; and an actuator for ejecting the drug depot from the stylet to a site within the body using fluid pressure. Also disclosed are methods using, and uses of, the delivery system, including for treating scoliosis.

Disclosed herein is a syringe device comprises (a) an outer housing, (b) a barrel, (c) a stopper, and (d) a plunger with one or more grooves.

A syringe assembly includes a barrel having a barrel tip portion, a puncture needle projecting from the barrel tip portion, and a cap that is detachably mountable to the barrel so as to seal a distal end of a needle hole. The cap has a receiving hole that receives the puncture needle, a bottom wall portion into which the puncture needle is inserted, and a stopper portion that defines an insertion length of the puncture needle relative to the bottom wall portion. In a state in which the cap is mounted to the barrel, the length from the most proximal position of a contact region between the cap and the puncture needle to the most proximal position of an edge surface is 1 to 3 mm.

An intradermal injection device comprising a unitary body having an open distal end and a proximal end having a skin engaging surface defined thereon, a reservoir defined between the proximal and distal ends for accommodating a drug substance, and a channel defined at the proximal end of the unitary body and extending through, and distally from, the skin engaging surface to the reservoir. A needle cannula having a sharpened proximal end and a distal end may be provided in the channel. The needle cannula is secured in the channel with the distal end being in communication with the reservoir and the proximal end of the needle cannula extending from the skin engaging surface a distance in the range of about 0.5 mm to 3.0 mm such that the skin engaging surface limits penetration of the proximal end of the needle cannula to the dermis layer of the skin of a patient.

A filtering needle assembly for use in administering a liquid payload, including: a needle and connector portion; a filtering needle body cap; a seal plug, and a filter: The seal plug initially lacking a needle channel so that a distal end of a hollow needle must be forced through the distal end of the seal plug while the seal plug is retained by a holding tool with a hollow midline of adequate depth to receive the protruding end of the hollow needle. An attempt to reuse the filtering needle assembly with a second insertion of a hollow needle into the filtering needle assembly will not work as the distal end of the hollow needle will push the seal plug distally rather than traverse the seal plug.

A system with a needle head that attaches to a syringe assembly. The syringe assembly contains a barrel and a plunger. The plunger has a bore opening that is accessible from within the barrel. A tubular spacer is disposed within the barrel. The tubular spacer defines a central opening. The needle head has a needle that extends from a needle base. The needle base extends into the central opening of the tubular spacer. A plug is provided that blocks access to the needle. The plug is displaced out of the central opening of the tubular spacer and into the opening in the plunger as the plunger contacts and displaces the tubular spacer in the barrel. As the plug is displaced from the tubular spacer, the plug transfers into the bore opening within the plunger. This enables the plunger to press flush against the tubular spacer.

A sealing cap for a syringe comprising a housing and a sealing insert received within the cavity of the housing. The housing comprises a connection portion and an insert-engagement portion, and the sealing insert comprises a tip-engagement portion and a housing-engagement portion. The housing-engagement portion of the sealing insert is received within the insert-engagement portion of the housing, and the tip-engagement portion of the sealing insert is received within the connection portion of the housing. An annular protrusion in the housing is received in an annular groove in the sealing insert. An annular locking rib extends around an outer periphery of a proximal end of the sealing insert and is positioned proximally beyond the proximal end of the housing. The engagement of the annular protrusion and the groove and between the housing and the locking rib hold the sealing insert within the housing. Also, a syringe including the sealing cap.