Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the catheter are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element.

A fluid dispensing device having a barrel having a lumen for containing a fluid therein and a flexible structure extending from the barrel. A plunger is axially slidable within the lumen to dispense fluid from the barrel, the plunger having a first set of grooves spaced apart a first distance and a second set of grooves spaced apart a second distance. The flexible structure includes a flexible arm extending transversely with respect to the barrel and configured to engage the grooves.

An injection device for injecting a composition contained in a medical container comprising: a body configured to receive the medical container in a fixed position relative to the body, spring-loaded piston rod translationally movable inside the body along a spring axis, between a proximal rest position and a distal operative position wherein the spring-loaded piston rod engages a stopper of the medical container, and a selective blocking mechanism comprising a braking member selectively tiltable relative to the piston rod between a blocking position wherein the braking member impinges on the piston rod so as to prevent any translational movement of the spring-loaded piston rod in a distal direction by a bracing effect and a releasing position wherein the braking member disengages from the piston rod so as to allow the piston rod to move towards the distal operative position under the spring force.

Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the catheter are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element.

A container for delivering a medicament to a target location includes a housing having a proximal end and a distal end, the housing including a cap locking tab at the distal end, and a vial containing medicament. The container includes a plunger slidable within the vial from the proximal end to the distal end of the vial to dispel the medicament, an injection member associated with the distal end, such that medicament dispelled from the vial passes through the injection member to the target location, and a slidable interaction member associated with the distal end of the vial configured to slide with the vial. An interaction between the slidable interaction member and cap locking tab causes the cap locking tabs to bias outward, and placement of a safety cap on the container after use locks the safety cap onto the container via the interaction with the cap locking tabs. The container may further include a resistance feature to control movement of the plunger rod relative to the vial.

Various embodiments disclosed herein relate to needle-based injectors that incorporate a power assembly comprising a stored energy source and a rate control assembly. The power assembly may be further configured to allow the injection to be performed with more force than a user may be capable of delivering, while also allowing the user to maintain control of the injection process after the stored energy source has been released and the injection has begun, such the user may increase or decrease the rate of injection, or stop the injection, during the injection process. In various embodiments, the power assembly may comprise spring- or gas-based stored energy sources, and/or may comprise friction- or tension-based rate control assemblies. Described herein are also methods for injecting an agent using embodiments of the devices described here.

The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.

A kit includes a drug delivery device and a dispensing unit. The drug delivery device includes a housing, a resetting element and a piston rod and the dispensing unit includes a cartridge holder. The cartridge holder is to be mounted to the housing and to receive a cartridge filled with a drug. The piston rod is to move in a proximal direction out of the housing for ejecting the drug and the resetting element is configured to rotate relative to the housing when no dispensing unit is attached to the housing and to thereby move the piston rod back into the housing. The dispensing unit is configured to press axially against the resetting element upon mounting to the housing to move the resetting element in the distal direction into the housing, and thereby rotationally lock the resetting element with respect to the housing.

A drug delivery device includes an elongate, generally cylindrical, housing extending along a longitudinal axis between a distal end and a proximal end, and a balancing weight located within the housing. A center of mass of the drug delivery device is located radially offset from the longitudinal axis in a radial direction towards the balancing weight.

A container for delivering a medicament to a target location includes a housing having a proximal end and a distal end, the housing including a cap locking tab at the distal end, and a vial containing the medicament. The container includes a plunger slidable within the vial from a proximal end to a distal end of the vial to dispel the medicament, an injection member associated with the distal end of the vial, such that the medicament dispelled from the vial passes through the injection member to the target location, and a slidable interaction member associated with the distal end of the vial configured to slide with the vial. An interaction between the slidable interaction member and the cap locking tab causes the cap locking tab to bias outward, and placement of a safety cap on the container after use locks the safety cap onto the container via an interaction with the cap locking tab.