A prefilled syringe includes an outer cylinder, a gasket, a plunger, and a drug housed in the outer cylinder. The outer cylinder includes a flange part that is located at a proximal end part. The plunger includes a gasket pressing part and a shaft part that extends in a proximal end direction from a gasket pressing part. The shaft part includes indicator parts that are located on a proximal side of the gasket pressing part.

An incremental syringe configured for displacement of fluid, such as medicaments is disclosed. The syringe may comprise detents on the syringe plunger configured to provide tactile feedback, audible feedback, or both, for discrete units of fluid aspirated or injected to or from the syringe. In some embodiments, a second set of detents is included, and in some embodiments a third set of detents is included.

Coatings for syringe plunger tips, as well as syringes and syringe components including such coatings, are disclosed. A material of the coating may have at least one different material property than a material of the syringe component to which it is applied. The coatings may provide a reduced coefficient of friction between the coating and a surface of the syringe relative to the coefficient of friction between the uncoated component and the syringe surface. Methods for manufacturing a syringe or syringe component including such coatings, as well as methods for isolating a substance in a syringe from a syringe component, are also disclosed.

Various systems and methods for the pressure-regulated transfer of medical fluids are disclosed. The system can include an adapter assembly that connects with a medical container and with a syringe assembly. The syringe assembly can include a first reservoir and a second reservoir. In various embodiments, when the adapter assembly and the syringe assembly are coupled, the first reservoir and the container can exchange regulating fluid and the second reservoir and the container can exchange medical liquid from the medical container.

A sterile Intracervical Insemination (ICI) fertility kit, method of sterilization, and method of use for performing self-insemination. Each sterile kit comprises: up to three sets of individually wrapped sterile, disposable, syringes and semen collection jars; printed instructions; and a QR code. The collection jar comprises a snap-on lid, and an inner surface with seamless edges to prevent semen residue. The syringes and jars are sealed in plastic wraps permeable to air and gas, and impermeable to pathogens; and are sterilized via gamma radiation or ethylene oxide. Fresh or frozen, unwashed or washed, semen is deposited into the jar, pulled into the syringe, and administered cervically during a user's maximum monthly level of luteinizing hormone. The syringe distal end is designed to push all semen out of the syringe then plug the end closed, while preventing semen residue from collecting within the syringe. Large circular syringe handles facilitate stable handling.

Methods of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a vacuum chamber, (2) creating a seal between the vacuum chamber and a syringe barrel or a cartridge tube, (3) maneuvering the stopper into a proximal end of the syringe barrel or cartridge tube by a first differential pressure and/or an insertion rod, (4) maneuvering the stopper through the barrel by second differential pressure and/or an insertion rod, (5) optionally sealing a pressure sealing cap to the proximal end of the vacuum chamber, (6) removing the vacuum chamber, insertion rod, and, if present, the pressure sealing cap. The methods are lubricant free or substantially lubricant free. The vacuum chamber may be electropolished and/or extrude honed.

Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, a surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness, the inner surface of the barrel having a surface roughness Ra of less than 100 nm.

A stopper/piston (510) having a cylindrical body (511) having a front axial end closed by a front wall (513). The hollow cylindrical body (511) includes an outside surface provided with a secondary sealing profile (610), the front wall (513) including a front axial outside surface (631) provided with a coating (635). The front wall (513) includes a primary sealing profile (630) on its radially-outer edge, the front wall (513) and the cylindrical body (511) is made of different materials, the hollow cylindrical body (511) being overmolded on the front wall (513). The front axial outside surface (631) of the front wall (513) includes a deformation profile (633) arranged radially inside the primary sealing profile (630), the deformation profile adapted to deform radially for insertion of the stopper/piston (510) into a syringe body.

A method of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a hybrid insertion device, (2) lowering the body of the hybrid insertion device into a syringe barrel or cartridge tube to a position located past the barrel flange or top of the cartridge tube while stablishing a sealable connection with the syringe barrel or cartridge tube, (3) maneuvering the stopper past the distal opening of the hybrid insertion device using an insertion pin and deploying the stopper at a final position within the syringe barrel or cartridge tube under vacuum assistance, (4) fully retracting the insertion pin from the syringe barrel or cartridge tube, and (5) retracting the hybrid insertion device from syringe barrel or cartridge tube. The method is lubricant free or substantially lubricant free. The hybrid insertion device may be electropolished and/or extrude honed.