A gasket includes a flexible packing portion having a recess attached to a coupler of a plunger rod, and a core member harder than the packing portion. The recess has an internal circumferential surface with an internally threaded portion capable of being screwed on and thus engaging with an externally threaded portion provided on an external circumferential surface of the coupler. The core member has a helical shape defining the internal circumferential surface of the recess and the internally threaded portion provided on the internal circumferential surface. The packing portion defines a sliding surface brought into contact with an inner circumferential surface of a barrel, and the packing portion also covers an outer circumferential surface of the core member.

An automatic injection device with flow regulation is disclosed. The automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection needle also has a fluid path which fluidly connects the drug container to the patient via an insertion device, a potential energy source, and a regulator configured to restrict release of potential energy and restrict linear movement of the plunger and the pharmaceutical product into the fluid path at a proscribed pace. The regulator includes a clock escapement mechanism. The potential energy source may be a spring that surrounds the drug container and may be magnetically coupled to the plunger. The clock escapement mechanism is configured to control the spring at a regulated rate over a time interval using a gearbox and rotational-to-linear translator comprising a rack and a pinion.

Provided herein is a plunger assembly for advancing a plunger through a barrel, such as the barrel of a pre-filled syringe. The plunger assembly includes a stopper adapter defining an aperture. The stopper adapter includes a first restraining member adjacent to the aperture. The plunger assembly also includes a plunger rod having a first end, a second end, and a plunger rod head disposed adjacent the first end of the plunger rod. The plunger rod head includes a second restraining member engageable with the first restraining member of the stopper adapter. The plunger assembly is configured such that as the plunger rod head is moved axially within the aperture of the stopper adapter, the first restraining member of the stopper adapter engages the second restraining member of the plunger rod head to secure the plunger rod head within the aperture. A syringe assembly with a plunger assembly is also disclosed.

A pressure jacket includes a barrel having a proximal end, a distal end, and a sidewall extending substantially circumferentially between the proximal end and the distal end along a longitudinal axis. The pressure jacket also includes at least one retaining member having at least one first lug protruding radially outward relative to an outer surface of the sidewall. The at least one first lug has at least one third surface tapered axially relative to the longitudinal axis of the barrel in a proximal direction. The at least one first lug is configured for engagement with a locking mechanism associated with a port on a fluid injector to releasably lock the pressure jacket with the fluid injector. At least a portion of the at least one third surface axially ejects the pressure jacket upon rotation of the pressure jacket about the longitudinal axis.

A pressure jacket for use with a fluid injector includes a barrel having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end along a longitudinal axis. The pressure jacket includes at least one engagement member protruding from a terminal portion of the proximal end of the barrel in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end of the barrel. The at least one engagement member engages with a locking mechanism on the fluid injector to releasably lock the pressure jacket with the fluid injector. A taper of the at least one engagement member rotationally guides the barrel into self-alignment with the locking mechanism and axially ejects the barrel upon rotation of the barrel about the longitudinal axis.

A plunger rod system for syringes is provided. The system comprises at least one plunger and an associated rod for imparting force to the plunger. The rod comprises an end with a threaded member, and the threaded member comprises threads of a certain geometry that enable ease of installation of the rod within the plunger while also providing resistance to pull-out forces such as may be imparted when pulling or extracting the rod or plunger from a barrel.

A fat-harvesting syringe having a multi-functional plunger assembly. The plunger assembly comprises an outer plunger rod body, an inner central plunger rod and a piston seal assembly. The outer plunger rod body having a first and a second end. The first end having a central lumen all at its finger grip handle and at the second end having flanges that are expandable. Once the central plunger inner rod is inserted fully into central lumen of plunger rod body, the expandable flanges expands and engages with the piston seal assembly. Also when the inner plunger rod is retracted, the plunger body flanges retract back and disengages from piston seal assembly.

The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.