The present invention provides a drug delivery device (1) of the type in which a piston rod (10, 110) extends along a reference axis and is forced to rotate in an expelling direction about the reference axis during a dose expelling event to cause an expelling of drug from a drug reservoir (30, 130), and a resilient ratchet element (12) is operatively coupled with the piston rod (10, 110) and undergoes a deflecting motion comprising elastic deformation and recovery in response to an expelling of a predetermined dose increment, which deflecting motion occasions a velocity fluctuation of the piston rod (10, 110), comprising: a rotator module (50, 150) operatively coupled with the piston rod (10, 110) and configured to rotate about the reference axis against a rotation resisting force in response to a rotation of the piston rod (10, 110) in the expelling direction, the rotator module (50, 150) comprising a sensor system (70, 71; 170, 183; 270, 183) for monitoring a torque transferred by the piston rod (10, 110) during the dose expelling event, wherein the sensor system (70, 71; 170, 183; 270, 183) is configured to, from the monitored torque, identify occurrences of velocity fluctuation of the piston rod (10, 110) attributable to the deflecting motion of the resilient ratchet element 15 (12).

A system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a finger flange coupled to the syringe flange. Moreover, the system includes a stopper member disposed in the syringe interior. In addition, the system includes a plunger ratchet member coupled to the stopper member. The system also includes a plunger tube disposed coaxially around at least a portion of the plunger ratchet member and operatively coupled thereto.

A drive mechanism for a medicament delivery device is presented having an activation rod provided with external activation rod threads having a first thread helix angle, an activation knob rotationally locked with the activation rod, wherein the activation knob is configured to be moved between a first axial position relative to the activation rod in which the activation knob is prevented from rotation and a second axial position in which the activation knob is allowed to rotate in a first direction, an axially slidable drum which is rotationally locked, a dose drum rotationally locked relative to the activation rod, wherein the dose drum is configured to rotate relative to the slidable drum, an indicator drum provided with external indicator drum threads having a second thread helix angle, wherein rotation of the activation knob in the first direction causes concurrent first rotation of the activation rod and the dose drum in accordance with the first thread helix angle.

A drug solution injection device includes: a catheter that has a hollow shaft, a hollow needle portion disposed on a distal end of the hollow shaft, and a lumen formed inside each of the hollow shaft and the needle portion and containing a drug solution; and a wire that is inserted into the lumen and is advanced from a proximal end of the lumen toward a distal end side so as to discharge the drug solution in the lumen from a distal end of the needle portion.

A system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a finger flange coupled to the syringe flange. Moreover, the system includes a stopper member disposed in the syringe interior. In addition, the system includes a plunger ratchet member coupled to the stopper member. The system also includes a plunger tube disposed coaxially around at least a portion of the plunger ratchet member and operatively coupled thereto.

A handheld assembly for dispensing a medicament to a subject is provided. The assembly includes a unit dose cartridge device, a shell, a plunger, a dispense button, a drive member and an escapement that is movable and capable of cycling the dispense assembly thru multiple states of a dispense cycle.

A drive mechanism for an applicator for delivering multiple doses of medicament, comprising an axially moveable piston rod (2) having a non-circular cross-section and an external thread, a mounting member (4) with one member of a pair of blocking means, said pair comprising a toothed rim (4a, 3b) and at least one ratchet arm (3a, 4b); a drive sleeve (3) having an internal thread coupled with the thread of the piston rod (2), the drive sleeve (3) provided on the distal end with the other member of said pair of blocking means. A method of assembling the drive mechanism of the invention, in which the drive sleeve (3) together with the piston rod (2) and the piston rod guide (5) into the mounting member (4) are inserted from the side of the distal end of the applicator.

An injection apparatus (2) comprising a housing (4) and an injector sub-assembly (6), wherein the injector sub-assembly is located within the housing; the injector sub-assembly includes a needle (20), a syringe barrel (18) and a piston (40) located within the syringe barrel; the injector sub-assembly is slidably mounted within the housing between an operative configuration in which at least a portion of the needle projects from the housing, and a retracted configuration in which the injector sub assembly is wholly located within the housing; and wherein the housing includes a housing body and needle exit door (44) pivotally connected to the body such that the door closes a needle exit aperture defined by the housing body when the injector sub-assembly is in its retracted configuration and opens when the injector sub-assembly is in its operative configuration to permit the needle to exit the housing.

A drug delivery device includes a housing defining a shell having a proximal end and a distal end and a longitudinal axis extending between the proximal end and the distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing and operably coupled to the needle assembly, and an audible indicator operably coupled to the drive assembly. The needle assembly includes a syringe containing a medicament and a needle or a cannula. The drive assembly is movable between an initial position and a second position that results in the medicament being expelled from the syringe. Upon the drive assembly being positioned in the second position, the audible indicator engages the drive assembly to generate an audible sound indicating the medicament has been expelled from the syringe.

Various exemplary drug syringes with a mechanical stop for a second dose, drug products utilizing the same, and methods of using drug syringes with a mechanical stop for a second dose are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.