The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

In some examples, a medical dispensing device includes a housing and a trigger. A first engager of the device is configured to move axially as the trigger pivots. As the first engager moves, it engages a rod. A maximum proximal position of the rod is defined by a stop. A spring presses the first engager into the trigger such that either the trigger or the first engager rests against a stop limiting rotation of the trigger. A second engager moves axially as the trigger pivots. At the actuated position the second engager, defined by a stop, the second engager limits proximal movement of the rod. An assembly transfers movement of the trigger to the second engager after the trigger has pivoted a threshold amount. A member of the assembly distally moves the second engager. Until it is at the actuated position, the second engager enables the rod to proximally move.

The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: an elongated housing (30) extending in an axial direction (1, 2), a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in axial distal direction (1), a drive sleeve (60) extending in axial direction (1, 2) and being rotatably supported in the housing (30), a dose setting member (40) rotatably supported on a side wall portion (31) of the housing (30) and being rotatable with respect to an axis (41) extending in radial direction (r), wherein the drive sleeve (60) is operably releasable from the piston rod (80) and rotatably engageable with the dose setting member (40) for setting of the dose.

A drug delivery device with a housing configured to connect to a dispensing unit includes a compartment containing a fluid, a piston rod configured to move in a proximal direction for ejecting the fluid, and a dosing mechanism comprising an actuation member to be actuated by a user. The device includes a conversion mechanism configured to convert a movement of the actuation member to a movement of the piston rod. The conversion mechanism includes a dose selector member, which is rotationally fixed to the housing and axially movable with respect to the housing, and a dosing member, which is rotationally movable with respect to the dose selector member. The drug delivery device includes a friction reduction mechanism provided between the dose selector member and the dosing member to reduce friction between the dose selector member and the dosing member.

A drug delivery device has a housing with a longitudinal axis, a dose setting member actuatable by a user and rotatable around the longitudinal axis to set a dose to be delivered by the drug delivery device, a piston rod that is configured to be axially advanced in a proximal direction to deliver the set dose, and a dosing member for defining the axial advancement of the piston rod upon delivery of the set dose. The dosing member is axially movable along the longitudinal axis and rotationally movable around the longitudinal axis during dose setting, and the dosing member is rotationally fixed to the dose setting member during dose setting. The dosing member comprises a maximum dose stop that is configured to engage with a maximum stop feature provided at the housing to limit movement of the dosing member with respect to the housing upon setting a maximum dose.

One example device includes a housing defining at least a first chamber and a second chamber; an injector disposed within the housing and comprising: a hollow needle coupled to a first piston, the first piston disposed and translatable within the first chamber towards a first end of the first chamber, the first piston defining a void intersecting a hollow portion of the hollow needle; a first propellant disposed within the first chamber and positioned to force the first piston towards the first end of the first chamber in response to activation of the first propellant; a dispenser disposed within the housing and comprising: a second piston disposed and translatable within the second chamber towards a first end of the second chamber; a second propellant disposed within the second chamber and positioned to force the second piston towards the first end of the second chamber in response to activation of the second propellant; and wherein translation of the first piston to the first end of the first chamber exposes the void to the first end of the second chamber.

A dosing mechanism (6) for delivering a plurality of single metered doses includes a dose delivery mechanism; and a non-return mechanism (10), arranged to prevent the dose delivery mechanism from returning toward a primed position until a full metered dose has been delivered. The non-return mechanism includes a track defining an actuation path and a return path and an engagement member arranged to be received within the track. The track and engagement member are relatively moveable such that the engagement member is arranged to move along the actuation path during actuation of the dose delivery mechanism and along the return path during priming of the dose delivery mechanism. At least a portion of the actuation path is provided with a toothed profile to prevent reverse movement of the engagement member in the actuation path.

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

An auto-injector device including a syringe, a needle arranged in the vicinity of a first end of the syringe, and a plunger arranged within the syringe. A volume within the syringe between the plunger the needle accommodates medicine, such that movement of the plunger toward the needle dispenses medicine through the needle. A selection assembly configurable by a user to adjust an amount of medicine dispensed by the auto-injector device and depth to which the medicine is delivered. Also, a method for treating a skin lesion or skin disorder utilizing the auto-injector and a kit for patient administered treatment.

An auto-injector device including a syringe, a needle arranged in the vicinity of a first end of the syringe, and a plunger arranged within the syringe. A volume within the syringe between the plunger the needle accommodates medicine, such that movement of the plunger toward the needle dispenses medicine through the needle. A selection assembly configurable by a user to adjust an amount of medicine dispensed by the auto-injector device and depth to which the medicine is delivered. Also, a method for treating a skin lesion or skin disorder utilizing the auto-injector and a kit for patient administered treatment.