Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments the device has a housing having a top housing end, and a bottom housing end. The housing defines a housing channel. The device has a drug cartridge defining a depot channel aligned with the housing channel and configured to slidably accept the drug depot. The drug cartridge has at least a first occluding device configured to occlude the depot channel at a first position such that the drug depot cannot pass through the depot channel without force applied to the drug depot sufficient to deflect the first occluding device. The bottom end of the housing has a coupling configuration for engaging a cannula. A plunger has a push rod to expel the drug depot through the occluding device and the cannula.

A cassette including: a cartridge holder including a first end, a second end having a holder opening, and a holder columnar space located between the first end and the second end and capable of accommodating a drug cartridge, drug cartridge including: a cylinder including a first end at which an injection needle is insertable/extractable, a second end at which a cylinder opening is located, and a cylinder columnar space located between the first end and the second end; a drug placed in the cylinder columnar space; and a gasket being placed in the cylinder columnar space; a cassette cap capable of opening and closing the holder opening, the cassette cap including a first end having a cap opening that is opposed to the holder opening, a second end having a piston insertion opening, and a cap columnar space located between the first end and the second end.

An improved hypodermic syringe including finger-holding surfaces that substantially or completely surround the operator finger and include an interior tapered portion to better engage a finger, which facilitates one-handed use by allowing the same hand that holds the syringe to operate the plunger conveniently to accomplish both the distal (injecting) stroke and the proximal (aspirating) stroke.

An infusion pump can be configured to modulate a drive motor based on perceived infusion pressure requirements for quieter, more energy-efficient operation of the drive motor. The infusion pump can include an electrical motor having a variable output torque based on the electrical current input, a plunger head sensor configured to detect a force between a plunger driver and a plunger of a medicament container, and a control module configured to regulate the electrical current input to the electrical motor based on the detected force between the plunger driver and the plunger medicament container. The electrical current input for such an infusion pump can be incrementally reduced according to defined magnitudes of detected force.

A device for administering a fluid can include a cylinder, a piston displaceable in the cylinder and connected to a piston rod, and a tensioning device connected to the piston rod. The tensioning device includes a ramp rotatable via a motor, and a ramp track extending along a helical line. The tensioning device includes a roller which is in contact with the ramp track. To perform a tensioning procedure, the ramp track is rotated such that the roller runs on the region of inclination as far as the second plateau so the piston is moved to its rear end position. To perform a dispensing procedure, the ramp track is rotated until the roller runs over a transfer region and is accelerated toward the first plateau, thereby the piston is moved toward an open dispensing end. A control unit determines whether the tensioning procedure and/or dispensing procedure has taken place correctly.

Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments the device has a housing having a top housing end, and a bottom housing end. The housing defines a housing channel. The device has a drug cartridge defining a depot channel aligned with the housing channel and configured to slidably accept the drug depot. The drug cartridge has at least a first occluding device configured to occlude the depot channel at a first position such that the drug depot cannot pass through the depot channel without force applied to the drug depot sufficient to deflect the first occluding device. The bottom end of the housing has a coupling configuration for engaging a cannula. A plunger has a push rod to expel the drug depot through the occluding device and the cannula.

A drive unit for a medicament delivery device is presented having an elongated plunger rod extending in a longitudinal direction, a drive force element capable of applying a drive force on the elongated plunger rod, and an actuator operably connected to the elongated plunger rod for releasably holding the elongated plunger rod in an energized state when the drive force element is exerting a drive force on the elongated plunger rod. An activator is operably connected to the actuator for releasably holding the actuator in a holding position where the actuator is designed to be movable from the holding position in a direction generally transversal to the longitudinal direction upon a displacement of the activator for releasing the plunger rod.

An injection device including: a body including a syringe locator for receiving a syringe; and a firing mechanism including a rear cap, a plunger configured to be axially displaced in a forward direction relative to the rear cap and a driver system for driving the plunger forwards upon activation of the injection device, the firing mechanism configured to be directly or indirectly connected to the body such that an axial spacing of the rear cap and a barrel of the syringe is fixed during operation of the injection device, wherein, the firing mechanism and/or the body include first and second connection features allowing adjustment of a relative axial position of the firing mechanism and the syringe locator during assembly of the injection device.

A medicament delivery system is described. Embodiments of the medicament delivery system can include a smart user device and a medicament delivery assembly. The medicament delivery assembly can be implemented as a single-use cartridge that can be removably coupled to the smart user device. The smart user device can be configured to determine when to automatically administer a medicament stored in the medicament delivery assembly.

Disclosed is a method and an auto-injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod; and a processing unit coupled to the drive module and to the resistance sensor. The processing unit being configured to: control the drive module to move the plunger rod towards the extended plunger rod position with a plunger rod speed; determine plunger rod position; receive the resistance signal; and control the drive module to adjust movement of the plunger rod if the resistance signal is indicative of resistance against movement of the plunger rod above a high resistance threshold, wherein the high resistance threshold is based on the plunger rod position.