A spring assembly for an administering device includes a driving spring configured as a spiral spring and a spring shaft. An inner end of the spring is rotationally fixedly attached to the spring shaft. A spring sleeve extends around the circumferential region of the spring, wherein the outer end of the spring is connected to the spring sleeve in a rotationally fixed manner and a disk-type spring-sleeve cover is attached to the spring sleeve or the spring shaft. The flange and the spring-sleeve cover extend radially away from an axis of the spring shaft and the flange is arranged near a distal end of the spring shaft. A radial stop is arranged on the flange periphery, and a blocking element is arranged on the spring sleeve to be complementary to the radial stop for releasably rotationally securing to each other when the blocking element and the radial stop engage.

A fluid delivery device comprises a fluid reservoir for containing medicament. The fluid reservoir is sealed proximate one end with a sliding seal piston. A delivery path is configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device. A basal engine mechanism is configured to directly or indirectly move the sliding seal piston in the fluid reservoir at a controlled basal rate. A bolus mechanism configured to move the basal engine relative to the fluid reservoir and directly or indirectly move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time.

A syringe exostructure includes a main body which removably receives a syringe having a syringe barrel and a syringe plunger. A drive plunger is reciprocatably mounted on the main body, and a plunger bar is slidably received in an axial channel on the drive plunger. The plunger bar is configured to removably couple to the syringe plunger when the syringe is introduced into the main body. A drive pawl assembly is fixed to an upper surface of the drive plunger and transfers motion of the drive plunger to the plunger bar as the drive plunger is advanced. The locking pawl engages the plunger bar and allows the plunger bar to be advanced by the drive plunger but prevents the plunger bar from being retracted as the drive plunger is retracted.

An injection device includes a housing for receiving a syringe or cartridge for containing a medicament; a rotary driveshaft mounted for rotation relative to the housing; and an elongate coiled torsion spring having respective formations at opposite ends thereof, with a first formation being anchored in a seat on the rotary drive shaft and a second formation being anchored in a seat on a reaction component. In use relative rotation of the rotary driveshaft and the reaction component in one angular direction strains the torsion drive spring, and release of the strained torsion drive spring causes expression of medicament from the syringe or cartridge. The torsion spring is longitudinally resiliently compressible between its end formations whereby during assembly of the injection device, the torsion spring may be longitudinally compressed and then rotated, thereby urging the end formations of the torsion drive spring into engagement with the respective seats.

Systems, devices, and methods described herein relate to delivery of therapeutic agents. Such systems and devices can include needle-based delivery systems, in which a throttling assembly is configured to control a rate or needle insertion and/or a rate of drug extrusion.

A fluid delivery device comprises a fluid reservoir for containing medicament. The fluid reservoir is sealed proximate one end with a sliding seal piston. A delivery path is configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device. A basal engine mechanism is configured to directly or indirectly move the sliding seal piston in the fluid reservoir at a controlled basal rate. A bolus mechanism configured to move the basal engine relative to the fluid reservoir and directly or indirectly move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time.

An auto-injector device including a syringe, a needle arranged in the vicinity of a first end of the syringe, and a plunger arranged within the syringe. A volume within the syringe between the plunger the needle accommodates medicine, such that movement of the plunger toward the needle dispenses medicine through the needle. A selection assembly configurable by a user to adjust an amount of medicine dispensed by the auto-injector device and depth to which the medicine is delivered. Also, a method for treating a skin lesion or skin disorder utilizing the auto-injector and a kit for patient administered treatment.

A syringe exostructure includes a main body which removably receives a syringe having a syringe barrel and a syringe plunger. A drive plunger is reciprocatably mounted on the main body, and a plunger bar is slidably received in an axial channel on the drive plunger. The plunger bar is configured to removably couple to the syringe plunger when the syringe is introduced into the main body. A drive pawl assembly is fixed to an upper surface of the drive plunger and transfers motion of the drive plunger to the plunger bar as the drive plunger is advanced. The locking pawl engages the plunger bar and allows the plunger bar to be advanced by the drive plunger but prevents the plunger bar from being retracted as the drive plunger is retracted.

An injection device includes a housing for receiving a syringe or cartridge for containing a medicament; a rotary driveshaft mounted for rotation relative to the housing; and an elongate coiled torsion spring having respective formations at opposite ends thereof, with a first formation being anchored in a seat on the rotary drive shaft and a second formation being anchored in a seat on a reaction component. In use relative rotation of the rotary driveshaft and the reaction component in one angular direction strains the torsion drive spring, and release of the strained torsion drive spring causes expression of medicament from the syringe or cartridge. The torsion spring is longitudinally resiliently compressible between its end formations whereby during assembly of the injection device, the torsion spring may be longitudinally compressed and then rotated, thereby urging the end formations of the torsion drive spring into engagement with the respective seats.

An auto-injector device including a syringe, a needle arranged in the vicinity of a first end of the syringe, and a plunger arranged within the syringe. A volume within the syringe between the plunger the needle accommodates medicine, such that movement of the plunger toward the needle dispenses medicine through the needle. A selection assembly configurable by a user to adjust an amount of medicine dispensed by the auto-injector device and depth to which the medicine is delivered. Also, a method for treating a skin lesion or skin disorder utilizing the auto-injector and a kit for patient administered treatment.