Systems and methods for mixing and/or reconstituting drugs are presented. A system may include an injection device, a vial, a needle, and a base station. The device has a chamber containing a first material. The vial has a chamber containing a second material. A drive unit of the base station moves the vial and/or the housing of the device relative to each other into an activated position. In the activated position, the needle is fluidly connected with the vial's chamber, and the drive unit is connected to a driver that moves the plunger in the axial direction of the device such that during fluid connection of the needle with the vial's chamber the first material is expelled from the device's chamber into the vial's chamber or the second material is expelled from the vial's chamber into the device's chamber.

A dual chambered syringe includes: an inner barrel defining a first inner chamber, the inner barrel having an apertured stopper at its distal end, the inner barrel being open at its proximal end; a shaft adapted to fit within the inner barrel, the shaft having a distal end which is engageable with the aperture of the stopper; a device for controlling engaging and disengaging of the distal end of the shaft with the aperture of the stopper; an outer barrel concentric with the inner barrel defining a second inner chamber, the outer barrel having a distal end for receiving and dispensing fluids and a proximal end into which the distal end of the inner barrel is insertable into the second inner chamber; the apertured stopper engages the second inner chamber of the outer barrel and selectively prevents or permits the passage of fluids between the outer barrel second chamber and the inner barrel first chamber; the inner barrel having an engageable surface on its outside surface; and, the outer barrel having operatively associated therewith an engaging device for selective engagement and disengagement with the engageable surface on the inner barrel.

An ophthalmic device includes a housing configured to hold an injectant chamber configured to store an injectant, a plunger disposed within the injectant chamber, and a stopper coupled to a distal portion of the plunger. The device also includes a hypodermic needle disposed at a distal end of the housing, and a sample chamber located within the housing adjacent to the distal end. The housing, hypodermic needle, and sample chamber are arranged such that when the stopper is moved to a first depth within the housing, the sample chamber is configured to receive material via the hypodermic needle. The housing, hypodermic needle, and sample chamber are also arranged such that when the stopper is moved to a second depth within the housing exceeding the first depth, the injectant chamber is configured to dispense the injectant through the hypodermic needle.

Described herein are syringe devices, systems and methods. In general, the syringe may include a first chamber and a cartridge movable within the first chamber. The cartridge may include a cartridge chamber and a valve in fluid communication with the cartridge chamber and the first chamber and having an open configuration and a closed configuration. The valve may allow movement of a liquid out of the cartridge chamber while in a open configuration. The cartridge may also include a second end, movable within the cartridge chamber, and a locking mechanism having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration.

A device (200) for mixing first and second substances. The device comprises a first container (100) for storage of the first substance and a second container (150) received in the first container (100) and for storage of the second substance. An outlet (112) is disposed at the distal end of the first container (100). Valve means (180) are provided for closing a distal end of the second container (150) and a proximal end of the first container (100). A stopper means (166) closes a proximal end of the second chamber (152) and is movable with respect to the second container (150). An operating mechanism drives relative movement between the first and second containers for causing displacement of the second substance into the first chamber (102) through the valve means (180) when the outlet (112) is closed, for mixing the first and second substances in a mixing stroke of the device.

A syringe apparatus is provided for stirring and delivering single or multi-component compositions. The syringe apparatus comprises a syringe barrel, a plunger, a stirring paddle, and a connecting member. The plunger partially disposed within the syringe barrel is movable along an axial direction of the syringe barrel. The stirring paddle disposed within the syringe barrel has one end passing through the plunger and slidably disposed within the plunger. The syringe apparatus of the disclosure can stir the components and deliver the mixture safely for maintaining a good hygiene condition during the therapeutic process.

The present invention relates to a metering container (100-1, 100-2) for metering a viscous material component (103-1, 103-2), comprising a piston (105-1, 105-2) for pressing the material component (103-1, 103-2) from a storage container (111-1, 111-2) into a metering chamber (107-1, 107-2); and a metering plunger (109-1, 109-2) for indicating a quantity of the material component (103-1, 103-2) in the metering chamber (107-1, 107-2), via which the material component (103-1, 103-2) can be dispensed from the metering chamber (107-1, 107-2).

A cartridge for dispensing a pre-measured buffering agent together with a medical fluid such as dental anesthetic. The cartridge includes a sharp piercing element at one end, a frangible barrier proximate the piercing element, and a traveling closure. The buffering solution is in a chamber between the barrier and the closure. When loaded into a syringe and subjected to operating pressures, the barrier is pierced, enabling the buffering solution to mix with the medical fluid. Continued pressure propels a desired, controlled mixture into a tissue of a patient. A dye may be included for visual confirmation of mixing. The invention may be regarded as the cartridge, a syringe having the cartridge, or a kit, with or without a syringe, or cartridges having closures of different types.

A syringe assembly, comprising a syringe barrel having a forward end and a rearward end and being arranged along a longitudinal axis; a restricting element, moveably supported onto a portion of the syringe assembly and positionable in one of an injection disabling position and an injection enabling position in different operative orientations of the syringe assembly; a plunger rod assembly displaceable within the syringe barrel and operatively coupled with the restricting element; the plunger rod assembly having a restricting feature adapted to cooperate with the restricting element, such that when the restricting element in the injection disabling position, the plunger rod assembly is permitted to be displaced axially forwardly only up to a certain longitudinal extent relative to the syringe barrel and when the restricting element is in the injection enabling position, the plunger rod assembly is permitted to be further displaced axially forwardly relative to the syringe barrel.

A system for serially injecting liquids includes a syringe body, proximal and distal stopper members disposed in the syringe body, a first liquid in a distal chamber, a second liquid in a proximal chamber, a plunger member, and a needle hub assembly coupled to a distal needle interface of the syringe body. The plunger member includes a needle retention feature disposed in a plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. Manipulating the plunger member to insert the proximal stopper member distally relative to the syringe body initially expels the first liquid, then the second liquid. The needle is at least partially retractable into plunger interior.