Low-profile fluid injection systems and methods for injecting fluid into a tumor within a body comprising an elongate member, a plurality of fluid delivery members, and a plurality of fluid reservoirs. Each of the plurality of fluid reservoirs may be fluidly coupled to a single of fluid delivery lumen of a single fluid delivery member such that each of the fluid delivery members is fluidly independent of every other fluid delivery member. The plurality of fluid delivery members may be configured to extend out of a distal end of the elongate member into the tumor when the system is positioned in the body of a patient. A fluid delivery mechanism may be operably coupled to the plurality of fluid reservoirs in order to deliver fluids from the plurality of fluid reservoirs to the plurality of fluid delivery members and inject the fluids into the tumor.

This invention belongs to the field of medicine and surgical instruments, and is intended to provide a new route of drug administration through needles plated with specific metals, aiming at better drug distribution and absorption upon administration, more precisely in the eyeball and/or on the patient's skin in order to increase its efficacy in relation to other means of drug delivery known in the medical field, especially in skin, mucous and ocular diseases. The invention allows drug delivery to the skin and/or subcutaneous tissue, by means of a duly modified tattoo machine, which instead of ink, uses drugs, as a product to be inserted in the skin. In addition, the invention can be used to administer drugs directly to a person's eyeball, offering great practicality and agility to surgical procedures.

A kit system has a beginning level kit apparatus, an intermediate level kit apparatus, and an advanced kit apparatus. The beginning level kit apparatus has a first derma roller having a head with a plurality of needles each having a length of five tenths millimeters situated thereon. Additionally, the beginning level kit apparatus has a first chemical compound comprising vitamin A.sub.1 at a first potency. The beginning level kit apparatus also has a first red light therapy device that that is configured to emit red light having a wavelength in the range of six hundred ten nanometers to seven hundred nanometers for a predetermined minimum time period of ten minutes. Finally, the beginning level kit apparatus has a beginning level enclosure apparatus that that encloses the first derma roller, the first chemical compound, and the first red light therapy device.

An administration device comprising an array of needles, one or more fluid agents, and at least one hydrogel is described. The device can simultaneously deliver a plurality of fluid agents along respective axes into a tissue. The use of hydrogel leads to constrained delivery of the fluid agents. The constrained delivery of an agent is also achieved by depositing a drug implant into a tissue. The effect of an agent on the tissue can be evaluated thereafter. In addition, the invention is directed to treating muscle diseases by delivering a therapeutic agent in vivo, and the use of reporter tissues for candidate drug evaluation, detecting and characterizing resistance.

The invention relates to an injection device which includes a handle and a guard which together enclose a movable cartridge which can contain liquid material to be injected, and further enclose a movable injector that includes a needle, the needle being attached to a housing where the housing is attached to the cartridge, the device also including a delivery mechanism whereby the needle is moved from a retracted to an extended position, and independently the volume of the chamber may be adjusted to expel the contents thereof through the needle and into a subject in need thereof. The injection device may be communicatively connected to a control unit so as to provide a dermal injection system.

The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises e a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.

This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.

An injection instrument set includes a tubular injection instrument in which an injection liquid is contained, and a guide member disposed on a surface of an injection target of the injection liquid. The injection instrument includes an injection needle which is inserted into the injection target to inject the injection liquid into the injection target. The guide member includes a guide passage which is disposed at a predetermined angle with respect to a surface of the guide member which comes into contact with the injection target and which allows the injection needle to be inserted and guides the injection needle onto the surface of the injection target, and an anti-slip portion disposed at a portion at which the guide member comes into contact with the surface of the injection target.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.