A syringe includes a syringe body, a syringe cone having a distal opening, and a connection arranged in the region of the syringe cone, wherein the syringe body includes a first material and the connection includes a second material, and wherein the first material is different from the second material and the second material is a softer material than the first material.

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes an injector cannula having a soft injector tip. A retractable tip protector tube is slidably disposed on the flow cannula between an extended position in which the tip protector tube covers the entire injector tip, and a retracted position in which the tip protector tube is retracted proximally thereby exposing at least part of the injector tip. Accordingly, the tip protector tube protects the injector tip from being damaged while advancing the injector tip to a target injection site.

A container holder assembly for a medicament delivery device is provided having a container holder and a needle assembly, where the container holder has a distal tubular body for receiving a multi-chamber container therein, the distal tubular body comprising a distal body engaging structure on an external surface configured to movably engage an actuator device of the medicament delivery device in order to releasably connect the container holder to the actuator device, and a proximal tubular part having a proximal body engaging structure connected to the needle assembly, where the needle assembly has a hub having an injection needle with a distal needle end and a proximal needle end, the distal needle end being isolated from the multi-chamber container when the multi-chamber container is received in the distal tubular body. A medicament delivery device having a container holder assembly is also provided.

A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

A multiple carrier injection system includes an adapter, having at least one arm, and a pen needle assembly. The pen needle assembly includes a hub retaining a needle and a bullet having a cover to seal the bullet, where the bullet encloses the hub in a first position. The arm engages the adapter to the hub, and the arm causes the hub to rotate within the bullet to move the hub into a second position.

Disclosed is a method of sealing a syringe barrel having a syringe tip with a collar. The syringe tip is sealed with a resilient closure. A tamper evident syringe tip cap comprising a cap member and a sleeve member separated by an annular first breaking line is then pushed over the resilient closure, to couple the proximal end of the sleeve member with the collar. The distal end of the resilient closure is accommodated in the cap member and protrudes beyond the sleeve member. The first breaking line is bridged by a coupling strip. For use of the syringe and providing access to the closure, the first breaking line is broken by pivoting the cap member away. The sleeve member remains coupled to the collar. Further tearing the cap member downward causes breaking a second breaking line provided in the sleeve member, thereby enabling removing the entire syringe tip cap.

Systems, devices, and techniques are disclosed for administering and tracking medicine to patients and providing health management capabilities for patients and caregivers. In some aspects, a system includes an injection pen device including a dose setting mechanism, a dispensing mechanism, and an electronics unit to generate dose data associated with a dispensing event of a dose of the medicine dispensed from the injection pen device and time data associated with the dispensing event; a mobile device in wireless communication to receive and process the dose data; and a software application configured to determine a recommended dose based on health data and contextual data associated with a user of the injection pen device, the software application including a learning dose calculator module to adaptively calculate the recommended dose of the medicine based on time-relevant and circumstances-relevant data specific to the user of the injection pen device.

The disclosure relates to a cartridge assembly for a drug delivery device, the cartridge assembly comprising a cartridge containing a drug; a cartridge holder, the cartridge holder defining an interior cartridge holding section, where the cartridge is arranged within the cartridge holding section, wherein the cartridge holder comprises a distal region with a needle connector arranged at a distal end of the distal region and a main body region; a fixing feature which is arranged at the distal region; and a region with reduced mechanical stiffness compared to the stiffness of the main body region, the region with reduced mechanical stiffness being integrated into the distal region and arranged between the needle connector and the fixing feature, such that when the cartridge is moved in a proximal direction, an emerging load is transferred from the cartridge to the fixing feature and to the main body region in the proximal direction.

Systems, devices, and techniques are disclosed for administering and tracking medicine to patients and providing health management capabilities for patients and caregivers. In some aspects, a system includes an injection pen device including a dose setting mechanism, a dispensing mechanism, and an electronics unit to generate dose data associated with a dispensing event of a dose of the medicine dispensed from the injection pen device and time data associated with the dispensing event; a mobile device in wireless communication to receive and process the dose data; and a software application configured to determine a recommended dose based on health data and contextual data associated with a user of the injection pen device, the software application including a learning dose calculator module to adaptively calculate the recommended dose of the medicine based on time-relevant and circumstances-relevant data specific to the user of the injection pen device.

A storage device (30) for storing a pen needle assembly (10) includes a housing (30) having first wells (44) with a dimension for receiving the pen needle assembly and second wells (46) for receiving an inner shield (24) of the pen needle assembly. The second wells (46) have a diameter less than a diameter of the first wells (44). An ejector (40) in the housing (34) can be actuated to eject the used needle hub (16) and outer covers (22) from the first well (44) and the inner shield (24) from the second well (46) for disposal. A method of coupling a pen needle delivery device to a needle hub positions a needle hub assembly (18) in the first well (44) and inserts the coupling end of the delivery device (10) into the first well (44) and is coupled to the needle hub. The needle hub is pulled from the outer cover (22). The inner shield (24) is inserted into the second well (46) to remove the inner shield from the needle hub.