The present invention relates to a filtering syringe, and more particularly, to an apparatus obtained by improving a syringe provided with a filter means for filtering foreign substances such as glass fragments of an ampoule, so as to prevent an injection needle or an injection flow passage from being contaminated with the foreign substances while allowing a liquid medicine to be smoothly sucked with a smaller force. The filtering syringe is configured such that the injection needle or the injection flow passage is isolated from the suction flow passage which is upstream of the filter means and in which the foreign substances may remain together with the liquid medicine, thereby allowing the liquid medicine to be sucked with a force less than that required for a conventional syringe and thus maximizing user's convenience and marketability of the syringe.

The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device. The pre-filled syringe comprises a container and a needle. The container is filled with a pharmaceutical composition comprising epinephrine, a buffer, and water. The buffer is configured to buffer in a pH range between 3 and 4. The needle is adhered to the container by means of a urethane acrylate or urethane methacrylate acrylic light cure adhesive, which is configured to provide a pull out resistance of the needle relative to the container which is between 30 N to 100 N, preferably between 50 N to 70 N, more preferably greater than 60 N after 90 days exposure to the pharmaceutical composition at 40 C. and 75% relative humidity (RH). In an example, the pharmaceutical composition is for the treatment of an anaphylactic event.

The present invention relates to adaptor (30) for a drug delivery device having a reservoir (12) and a longitudinal tip (20), the adaptor (30) comprising a distal part defining a connecting ring (31) intended to receive a connector, and a proximal part defining a mounting ring (33) having an inner surface (34), the mounting ring (33) being shaped and configured such that, when the adaptor (30) is mounted around the longitudinal tip (20) of the drug delivery device, at least one annular space (38) is created between said inner surface (34) of the mounting ring (33) and said outer surface (20a) of the longitudinal tip (20), said at least one annular space (38) being able to accommodate an adhesive layer (40) in order to bond said adaptor (30) to said longitudinal tip. The invention further relates to a drug delivery device comprising such an adaptor.

The invention faces the technical problem of providing a tight connection between a tube and an dispense interface, while at the same time the biocompatibility of the connection can be improved. The technical problem is solved by an apparatus comprising a tube configured to guide a medium and a dispense interface. The tube comprises a first opening and a second opening, while the dispense interface comprises a recess. The recess has a first opening and a second opening and the tube is at least in part inserted into the recess. The tube is permanently affixed to the dispense interface by a combination of an interference fit and an adhesive, such that the interference fit prevents the adhesive from contaminating the medium.

A needle assembly (1, 100) for an injection device comprising a needle cannula (10, 10), a hub (30, 130) comprising skirt portion (40, 140) and a central portion (60, 60). The skirt portion (40, 140) is having an internal surface (43, 143) adapted for connection to an injection device, wherein the skirt portion (40, 140) is having an open proximal end (41, 141) adapted to be sealed off by a sealing member (90, 190). The hub (30, 130) is having a distal end (42, 142) closed by the central portion (60, 160), wherein the central portion (60, 160) is adapted to receive the cannula (10, 110). The internal surface (43, 143) of the skirt portion (40, 140) comprises a connecting member, a cap portion (80, 180) for covering the distal end (12, 112) of the cannula (10, 110), a frangible zone (89, 189). The cap portion (80, 180) can be turned from an initial mode, wherein the frangible zone (89, 189) connects the cannula cap portion (80, 180) and the hub (30, 130), to a broken mode, wherein the frangible zone (89, 189) is broken, and wherein the cannula cap portion (80, 180) and the hub (30, 130) can be separated from each other. The sealing member (90, 190) is permeable to a sterilizing agent, and thereby adapted to enable sterilization of an internal space (5, 105).

An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

A cannula assembly includes a cannula, polymeric support material and a hub. The cannula has a proximal end and a distal end. The polymeric support material substantially surrounds a portion of the cannula at or near the proximal end. The hub is configured to be attached to a syringe. The polymeric support material is located between the cannula and the hub. The cannula, the polymeric support material and the hub are adhesively attached.

An injection needle is provided that allows design of the size of a needle base without being limited by the size of a syringe connecting part. As a hub, a needle base that is formed to have a through hole into which a needle tube is inserted, and a tubular housing where both ends in the axial direction are opened and the needle base is fitted and stored inside of one end, are formed as separate injection molded parts, thereby allowing the needle base to be largely designed. A needle tube shield part is in a box-lid shape, and the back side of a ceiling part thereof is provided with a tubular guiding part. An edge surface thereof abuts on the needle base, and a side part annularly holds and abuts on the housing. Accordingly, the needle base does not move upon receiving the pressure of a drug solution.

The present invention relates to a method of producing syringes. Said method comprises fixing a needle to a syringe body by use of an adhesive followed by subjecting the syringes thus obtained to heat treatment. The invention further relates to a method of reducing leachables and/or extractables in prefilled syringes, said method comprising heat treating pre-fabricated syringes at a temperature of at least 40 C. before filling.

A method of using a medicine injection device including a syringe filled with a medicine; a needle tube having a needle tip for puncturing the skin; a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when the living body is punctured with the needle tube; and an absorption part that is disposed in the skin contact portion of the needle hub. The method includes removing air from the medicine injection device prior to injection of the medicine, whereby medicine spilled from the needle tip is caught in the skin contact portion; the absorption part absorbing the spilled medicine staying in the skin contact portion; positioning the skin contact portion adjacent the skin; puncturing the skin with the needle tip; and injecting medicine from the needle tip into the skin.